The presentation of exogenous antigens on MHC class I molecules, known as cross-
presentation, is essential for the initiation of CD8+ T cell responses. In vivo, cross …

T cell recognition of antigen-presenting cells depends on their expression of a spectrum of
peptides bound to major histocompatibility complex class I (MHC-I) and class II (MHC-II) …

Adjuvants are indispensable components of vaccines for stimulating optimal immune
responses to non-replicating, inactivated and subunit antigens. Eliciting balanced humoral …

Over several decades, various forms of genomic analysis of the human major
histocompatibility complex (MHC) have been extremely successful in picking up many …

Dendritic cells are at the center of immune responses. They are defined by their ability to
sense the environment, take up and process antigen, migrate to secondary lymphoid …

Phagocytes, particularly dendritic cells (DCs), generate peptide-major histocompatibility
complex (MHC) I complexes from antigens they have collected from cells in tissues and …

Interest in MHC-E–restricted CD8+ T cell responses has been aroused by the discovery of
their efficacy in controlling simian immunodeficiency virus (SIV) infection in a vaccine model …

The invariant chain (CD74) is well known for its essential role in antigen presentation by
mediating assembly and subcellular trafficking of the MHCII complex. Beyond this, CD74 …

As a population, dendritic cells (DC s) appear to be the best cross‐presenters of internalized
antigens on major histocompatibility complex class I molecules in the mouse. To do this, DC …

Circulating platelets interact with leukocytes to modulate host immune and thrombotic
responses. In sepsis, platelet-leukocyte interactions are increased and have been …