Microglia are resident immune cells in the central nervous system (CNS) that are capable of
carrying out prominent and various functions during development and adulthood under both …

Microglia are the primary innate immune cells in the CNS. In the healthy brain, they exhibit a
unique molecular homeostatic 'signature', consisting of a specific transcriptional profile and …

Brain aging is a complex process that affects everything from the subcellular to the organ
level, begins early in life, and accelerates with age. Morphologically, brain aging is primarily …

Lipids constitute the bulk of the dry mass of the brain and have been associated with healthy
function as well as the most common pathological conditions of the brain. Demographic …

Alzheimer's disease (AD) is the most prevalent form of dementia, with complex
pathophysiology that is not fully understood. While β‐amyloid plaque and neurofibrillary …

Microglia are resident macrophages of the CNS that are involved in its development,
homeostasis and response to infection and damage. Microglial activation is a common …

Lipid droplets are dynamic intracellular lipid storage organelles that respond to the
physiological state of cells. In addition to controlling cell metabolism, they play a protective …

Gene expression analyses of microglia, the tissue-resident macrophages of the central
nervous system (CNS), led to the identification of homeostatic as well as neurological …

Neurological manifestations are a significant complication of coronavirus disease (COVID-
19), but underlying mechanisms aren't well understood. The development of animal models …

The present study was designed to investigate the role of β‐amyloid (Aβ1‐42) in inducing
neuronal pyroptosis and its mechanism. Mice cortical neurons (MCNs) were used in this …