Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

High-fat, low-carbohydrate diets, known as ketogenic diets, have been used as a non-
pharmacological treatment for refractory epilepsy. A key mechanism of this treatment is …

The past 20 years have resulted in unprecedented progress in understanding brain energy
metabolism and its role in health and disease. In this review, which was initiated at the 14th …

New insights into the mechanisms of the ketogenic diet : Current Opinion in Neurology New
insights into the mechanisms of the ketogenic diet : Current Opinion in Neurology Log in or …

The ketogenic diet (KD) has been important in treating epilepsy since the 1920s. The
benefits of KD further expanded to other neurological diseases, including Alzheimer's …

Cells integrate nutrient sensing and metabolism to coordinate proper cellular responses to a
particular nutrient source. For example, glucose drives a gene expression program …

Background Dietary restriction (DR), a reduction in food intake without malnutrition,
increases most aspects of health during aging and extends lifespan in diverse species …

Antiseizure drugs (ASDs), also termed antiepileptic drugs, are the main form of symptomatic
treatment for people with epilepsy, but not all patients become free of seizures. The …

Abstract See Rogawski (doi: 10.1093/awv369) for a scientific commentary on this article. The
medium chain triglyceride ketogenic diet is an established treatment for drug-resistant …

The high-fat ketogenic diet (KD) is a remarkably effective treatment for medically intractable
epilepsy and has been part of the clinical armamentarium for nearly a century. However, the …