Cisplatin (CP) is a well-known chemotherapeutic agent with excellent clinical effects. The
anti-tumor activity of CP has been demonstrated in different cancers such as breast, cervical …

Cancer as we know it is actually an umbrella term for over 100 very unique malignancies in
various tissues throughout the human body. Each type, and even subtype of cancer, has …

Background: Dysregulated microRNA (miRNA) expression in cancer can act as a key factor
that modifies biological processes, including chemoresistance. Our study aimed to identify …

Epigenetic factor Brd4 has emerged as a key regulator of cancer cell proliferation. Targeted
inhibition of Brd4 suppresses growth and induces apoptosis of various cancer cells. In …

To survive, cancer cells are subjected to various internal and external adverse factors,
including genetic mutations, hypoxia, nutritional deficiencies, and drug toxicity. All of these …

Autophagy is a conserved catabolic process involving the degradation and recycling of
damaged biomacromolecules or organelles through lysosomal-dependent pathways and …

Lung cancer is a major public health problem and a leading cause of cancer-related deaths
worldwide. Despite advances in treatment options, the five-year survival rate for lung cancer …

Lung cancer is the most frequently diagnosed malignancy and the leading source of cancer-
associated mortality. This kind of cancer has heterogeneous nature and is divided into two …

Platinum-based drugs are the first line of therapeutics against many cancers, including lung
cancer. Lung cancer is one of the leading causes of cancer-related death worldwide …

Background: Platinum-based chemotherapy, cisplatin (DDP) specifically, is the main
strategy for treating lung cancer (LC). However, currently, there is a lack of predictive drug …