Proteomic analysis of cells, tissues and body fluids has generated valuable insights into the
complex processes influencing human biology. Proteins represent intermediate phenotypes …

Glycomics aims to identify the structure and function of the glycome, the complete set of
oligosaccharides (glycans), produced in a given cell or organism, as well as to identify …

Immunoglobulin (IgG) glycosylation is a complex enzymatically controlled process, essential
for the structure and function of IgG. IgG glycome is relatively stable in the state of …

The presence of fucose on IgG1 Asn-297 N-linked glycan is the modification of the human
IgG1 Fc structure with the most significant impact on FcɣRIII affinity. It also significantly …

Ageing phenotypes, such as years lived in good health (healthspan), total years lived
(lifespan), and survival until an exceptional old age (longevity), are of interest to us all but …

Prostate-specific antigen (PSA) screening for prostate cancer remains controversial because
it increases overdiagnosis and overtreatment of clinically insignificant tumors. Accounting for …

The recombination between immunoglobulin (IG) gene segments determines an individual's
naïve antibody repertoire and, consequently,(auto) antigen recognition. Emerging evidence …

There is increasing evidence that pleiotropy, the association of multiple traits with the same
genetic variants/loci, is a very common phenomenon. Cross-phenotype association tests are …

Post-translational modifications diversify protein functions and dynamically coordinate their
signalling networks, influencing most aspects of cell physiology. Nevertheless, their genetic …

Effector functions of immunoglobulin G (IgG) are regulated by the composition of a glycan
moiety, thus affecting activity of the immune system. Aberrant glycosylation of IgG has been …