Eph receptors and ephrins: therapeutic opportunities

A Barquilla, EB Pasquale - Annual review of pharmacology and …, 2015 - annualreviews.org
The e rythropoietin-p roducing h epatocellular carcinoma (Eph) receptor tyrosine kinase
family plays important roles in developmental processes, adult tissue homeostasis, and …

Eph receptors in cancer

S Arora, AM Scott, PW Janes - Biomedicines, 2023 - mdpi.com
Eph receptor tyrosine kinases play critical functions during development, in the formation of
tissue and organ borders, and the vascular and neural systems. Uniquely among tyrosine …

The potential role of COVID-19 in progression, chemo-resistance, and tumor recurrence of oral squamous cell carcinoma (OSCC)

A Norouzi, M Liaghat, M Bakhtiyari… - Oral Oncology, 2023 - Elsevier
Numerous studies have revealed that cancer patients are more likely to develop severe
Coronavirus disease-2019 (COVID-19), which can cause mortality, as well as cancer …

The role of Eph receptors in cancer and how to target them: novel approaches in cancer treatment

OJ Buckens, B El Hassouni, E Giovannetti… - Expert opinion on …, 2020 - Taylor & Francis
Introduction Erythropoietin-producing human hepatocellular (Eph) receptors are among the
largest family of tyrosine kinases that are divided into two classes: EphA and EphB …

Reduction of circulating Cancer cells and metastases in breast-Cancer models by a potent EphA2-agonistic peptide–drug conjugate

AF Salem, S Wang, S Billet, JF Chen… - Journal of medicinal …, 2018 - ACS Publications
EphA2 overexpression has been associated with metastasis in multiple cancer types,
including melanomas and ovarian, prostate, lung, and breast cancers. We have recently …

The efficacy of receptor tyrosine kinase EphA2 autophosphorylation increases with EphA2 oligomer size

E Zapata-Mercado, G Biener, DM McKenzie… - Journal of Biological …, 2022 - ASBMB
The receptor tyrosine kinase (RTK) EphA2 is expressed in epithelial and endothelial cells
and controls the assembly of cell–cell junctions. EphA2 has also been implicated in many …

Integration of functional peptides into nucleic acid-based nanostructures

JS Freitag, C Möser, R Belay, B Altattan, N Grasse… - Nanoscale, 2023 - pubs.rsc.org
In many applications such as diagnostics and therapy development, small peptide fragments
consisting of only a few amino acids are often attractive alternatives to bulky proteins. This is …

Targeting the Eph system with peptides and peptide conjugates

SJ Riedl, EB Pasquale - Current drug targets, 2015 - ingentaconnect.com
Eph receptor tyrosine kinases and ephrin ligands constitute an important cell communication
system that controls development, tissue homeostasis and many pathological processes …

Engineering nanomolar peptide ligands that differentially modulate EphA2 receptor signaling

M Gomez-Soler, MP Gehring, BC Lechtenberg… - Journal of Biological …, 2019 - ASBMB
The EPH receptor A2 (EphA2) tyrosine kinase plays an important role in a plethora of
biological and disease processes, ranging from angiogenesis and cancer to inflammation …

Potent and selective EphA4 agonists for the treatment of ALS

B Wu, SK De, A Kulinich, AF Salem, J Koeppen… - Cell chemical …, 2017 - cell.com
Amyotrophic lateral sclerosis (ALS) is a progressive degenerative disease that affects motor
neurons. Recent studies identified the receptor tyrosine kinase EphA4 as a disease …