TGF-β-mediated epithelial-mesenchymal transition and cancer metastasis
Transforming growth factor β (TGF-β) is a secreted cytokine that regulates cell proliferation,
migration, and the differentiation of a plethora of different cell types. Consistent with these …
migration, and the differentiation of a plethora of different cell types. Consistent with these …
Targeting metastasis
PS Steeg - Nature reviews cancer, 2016 - nature.com
Tumour metastasis, the movement of tumour cells from a primary site to progressively
colonize distant organs, is a major contributor to the deaths of cancer patients. Therapeutic …
colonize distant organs, is a major contributor to the deaths of cancer patients. Therapeutic …
A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-κB signaling
P Altea-Manzano, G Doglioni, Y Liu, AM Cuadros… - Nature cancer, 2023 - nature.com
Metabolic rewiring is often considered an adaptive pressure limiting metastasis formation;
however, some nutrients available at distant organs may inherently promote metastatic …
however, some nutrients available at distant organs may inherently promote metastatic …
Fatty acid synthesis is required for breast cancer brain metastasis
Brain metastases are refractory to therapies that control systemic disease in patients with
human epidermal growth factor receptor 2-positive breast cancer and the brain …
human epidermal growth factor receptor 2-positive breast cancer and the brain …
The dynamic and stress-adaptive signaling hub of 14-3-3: emerging mechanisms of regulation and context-dependent protein–protein interactions
3-3 proteins are a family of structurally similar phospho-binding proteins that regulate
essentially every major cellular function. Decades of research on 14-3-3s have revealed a …
essentially every major cellular function. Decades of research on 14-3-3s have revealed a …
TGF-β family signaling in tumor suppression and cancer progression
J Seoane, RR Gomis - Cold Spring Harbor perspectives …, 2017 - cshperspectives.cshlp.org
Transforming growth factor-β (TGF-β) induces a pleiotropic pathway that is modulated by the
cellular context and its integration with other signaling pathways. In cancer, the pleiotropic …
cellular context and its integration with other signaling pathways. In cancer, the pleiotropic …
Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells
Metastases are the leading cause of mortality in patients with cancer. Metastasis formation
requires cancer cells to adapt their cellular phenotype. However, how metabolism supports …
requires cancer cells to adapt their cellular phenotype. However, how metabolism supports …
Mapping molecular subtype specific alterations in breast cancer brain metastases identifies clinically relevant vulnerabilities
The molecular events and transcriptional plasticity driving brain metastasis in clinically
relevant breast tumor subtypes has not been determined. Here we comprehensively dissect …
relevant breast tumor subtypes has not been determined. Here we comprehensively dissect …
TGF-β signaling in cancer metastasis
The transforming growth factor (TGF)-β signaling events are well known to control diverse
processes and numerous responses, such as cell proliferation, differentiation, apoptosis …
processes and numerous responses, such as cell proliferation, differentiation, apoptosis …
Fibroblast-derived IL33 facilitates breast cancer metastasis by modifying the immune microenvironment and driving type 2 immunity
O Shani, T Vorobyov, L Monteran, D Lavie, N Cohen… - Cancer research, 2020 - AACR
Lungs are one of the main sites of breast cancer metastasis. The metastatic
microenvironment is essential to facilitate growth of disseminated tumor cells. Cancer …
microenvironment is essential to facilitate growth of disseminated tumor cells. Cancer …