Matrix metalloproteinases are versatile endopeptidases with many different functions in the
body in health and disease. In the brain, matrix metalloproteinases are critical for tissue …

Traumatic brain injury (TBI) is the leading cause of death in young adults and children. The
treatment of TBI in the acute phase has improved substantially; however, the prevention and …

Pneumococcal meningitis continues to be associated with high rates of mortality and long-
term neurological sequelae. The most common route of infection starts by nasopharyngeal …

The blood-brain barrier (BBB) is formed by the endothelial cells of cerebral microvessels,
providing a dynamic interface between the peripheral circulation and the central nervous …

Deleterious processes of extracellular proteolysis may contribute to the progression of tissue
damage after acute brain injury. We recently showed that matrix metalloproteinase-9 (MMP …

Tight junctions create a paracellular barrier in epithelial and endothelial cells protecting
them from the external environment. Two different classes of integral membrane proteins …

Matrix metalloproteinases (MMPs) are a gene family of neutral proteases that are important
in normal development, wound healing, and a wide variety of pathological processes …

Matrix metalloproteinases (MMPs) are matrix‐degrading enzymes involved in diverse
homeostatic and pathological processes. Several MMPs are expressed within the CNS and …

Matrix metalloproteinases (MMPs), originally discovered to function in the breakdown of
extracellular matrix proteins, have gained the status of regulatory proteases in signaling …

A wide range of central nervous system (CNS) disorders include neuroinflammatory events
that perturb blood–brain barrier (BBB) integrity. Mechanisms by which the BBB responds to …