The tumor suppressor p53 maintains an equilibrium between self-renewal and
differentiation to sustain a limited repertoire of stem cells for proper development and …

TP53, TP63, and TP73 genes comprise the p53 family. Each gene produces protein
isoforms through multiple mechanisms including extensive alternative mRNA splicing …

BACKGROUND & AIMS:: Infection with the gastric mucosal pathogen Helicobacter pylori is
the strongest identified risk factor for distal gastric cancer. These bacteria colonize a …

Simple Summary The p53 family is a complex family of transcription factors with different
cellular functions that are involved in several physiological processes. A massive amount of …

Abstract p73, along with p53 and p63, belongs to the p53 family of transcription factors.
Besides the p53-like tumor suppressive activities, p73 has unique roles, namely in neuronal …

Multidrug resistance (MDR) caused by overexpression of p-glycoprotein is a major obstacle
in chemotherapy of malignant cancer, which usually is characterized by constitutive …

Abstract p73 is the older sibling of p53 and mimics most of its tumor-suppressor functions.
Through alternative promoter usage and splicing, the TP73 gene generates more than two …

Cancer stem–like cells (CSC) have been proposed to promote cancer progression by
initiating tumor growth at distant sites, suggesting that stem-like cell features can support …

Although the p53 tumor suppressor is relatively well characterized, much less is known
about the functions of other members of the p53 family, p73 and p63. Here, we present …

Gastroesophageal reflux disease (GERD) is the strongest known risk factor for esophageal
adenocarcinoma. In the center of tumorigenic events caused by GERD is repeated damage …