Histone posttranslational modifications are key components of diverse processes that
modulate chromatin structure. These marks function as signals during various chromatin …

Cell cycle checkpoints activated by DNA double-strand breaks (DSBs) are essential for the
maintenance of the genomic integrity of proliferating cells. Following DNA damage, cells …

Histone H2AX phosphorylation on a serine four residues from the carboxyl terminus
(producing γH2AX) is a sensitive marker for DNA double-strand breaks (DSBs). DSBs may …

DNA double-strand breaks (DSBs) are extremely dangerous lesions with severe
consequences for cell survival and the maintenance of genomic stability. In higher …

Genome integrity is constantly monitored by sophisticated cellular networks, collectively
termed the DNA damage response (DDR). A common feature of DDR proteins is their …

BRCA1 promotes homologous recombination (HR) by activating DNA-end resection. By
contrast, 53BP1 forms a barrier that inhibits DNA-end resection. Here, we show that BRCA1 …

Signaling pathways that respond to DNA damage are essential for the maintenance of
genome stability and are linked to many diseases, including cancer. Here, a genome-wide …

The control of biological events requires strict regulation using complex protein
phosphorylation and dephosphorylation strategies. The bulk of serine-threonine …

Expression of BRCA1 is commonly decreased in sporadic breast tumors, and this correlates
with poor prognosis of breast cancer patients. Here we show that BRCA1 transcripts are …

DNA repair and maintenance of genome stability are crucial to cellular and organismal
function, and defects in these processes have been implicated in cancer and ageing …