In this review, we comprehensively present the function of epigenetic regulations in normal
placental development as well as in a prominent disease of placental origin, preeclampsia …

Vasculogenesis and angiogenesis are key processes of placental development, which
occur throughout pregnancy. Placental vasculogenesis occurs during the first trimester of …

Homeobox genes regulate embryonic and placental development, and are widely
expressed in the human placenta, but their regulatory control by DNA methylation is unclear …

The placenta provides critical transport functions between the maternal and fetal circulations
during intrauterine development. Formation of this interface is controlled by nuclear …

Fetal growth restriction (FGR), a clinically significant pregnancy disorder, is poorly
understood at the molecular level. This study investigates idiopathic FGR associated with …

Homeobox genes are essential for both the development of the blood and lymphatic
vascular systems, as well as for their maintenance in the adult. Homeobox genes comprise …

Gestational diabetes mellitus (GDM) is a significant pregnancy complication linked to
perinatal complications and an elevated risk of future metabolic disorders for both mothers …

DLX3, a member of the large homeobox gene family of transcription factors, is necessary for
normal placentation. Targeted deletion of DLX3 in mouse resulted in embryonic death due …

Low birthweight and reduced height gain during infancy (stunting) may arise at least in part
from adverse early life environments that trigger epigenetic reprogramming that may favor …

Fetal growth restriction (FGR) is a clinically important human pregnancy disorder that is
thought to originate early in pregnancy and while its aetiology is not well understood, the …