Background Septic shock is the most severe form of sepsis, in which profound underlying
abnormalities in circulatory and cellular/metabolic parameters lead to substantially …

For more than two decades, sepsis was defined as a microbial infection that produces fever
(or hypothermia), tachycardia, tachypnoea and blood leukocyte changes. Sepsis is now …

Background Sepsis is life-threatening organ dysfunction due to a dysregulated host
response to infection. It is considered a major cause of health loss, but data for the global …

Importance Estimates from claims-based analyses suggest that the incidence of sepsis is
increasing and mortality rates from sepsis are decreasing. However, estimates from claims …

Objectives: We performed a national cross-sectional survey to determine the epidemiologic
characteristics of patients with sepsis in ICU in China. Design: A cross-section survey study …

Rationale: Reducing the global burden of sepsis, a recognized global health challenge,
requires comprehensive data on the incidence and mortality on a global scale. Objectives …

Neutrophil extracellular traps (NETs; webs of DNA coated in antimicrobial proteins) are
released into the vasculature during sepsis where they contribute to host defense, but also …

Complex genetic and physiological variations as well as environmental factors that drive
emergence of chromosomal instability, development of unscheduled cell death, skewed …

Purpose To determine the association between compliance with the Surviving Sepsis
Campaign (SSC) performance bundles and mortality. Design Compliance with the SSC …

Background Sepsis, the most severe manifestation of acute infection, poses a major
challenge to health care systems around the world. To date, adequate data on the incidence …