In primary Sjögren syndrome (pSS), chronic inflammation of exocrine glands results in tissue
destruction and sicca symptoms, primarily of the mouth and eyes. Fatigue, arthralgia and …

Primary Sjögren syndrome (pSS) is a prototypical autoimmune disease. The involvement of
B cells in the pathogenesis of pSS has long been suspected on the basis of clinical …

Primary Sjögren's syndrome (pSS) is a chronic systemic autoimmune rheumatic disease
characterized by lymphoplasmacytic infiltration of the salivary and lacrimal glands, whereby …

Naive T cells have long been regarded as a developmentally synchronized and fairly
homogeneous and quiescent cell population, the size of which depends on age, thymic …

Primary Sjögren's syndrome (pSS) is a complex disabling systemic autoimmune disorder.
The hallmark of pSS is the T-cell-mediated hyperactivation of B-cells, evolving from …

Microglia are tissue macrophages of the central nervous system (CNS) that control tissue
homeostasis. Microglia dysregulation is thought to be causal for a group of neuropsychiatric …

Objectives Increasing evidence suggests an epigenetic contribution to the pathogenesis of
autoimmune diseases, including primary Sjögren's Syndrome (pSS). The aim of this study …

Immune-mediated diseases are clinically heterogeneous but they share genetic and
pathogenic mechanisms. These diseases may develop from the interplay of genetic factors …

Recent evidence suggests that neutrophils play an important role in the pathogenesis of
lupus. The goal of this study was to characterize the epigenetic architecture, by studying the …

Background The aetiology of systemic sclerosis (SSc) is not clear, but there is an emerging
evidence of gene-specific epigenetic dysregulation in the pathogenesis of SSc. Methods We …