[HTML][HTML] The different autophagy degradation pathways and neurodegeneration
The term autophagy encompasses different pathways that route cytoplasmic material to
lysosomes for degradation and includes macroautophagy, chaperone-mediated autophagy …
lysosomes for degradation and includes macroautophagy, chaperone-mediated autophagy …
NRF2, a transcription factor for stress response and beyond
F He, X Ru, T Wen - International journal of molecular sciences, 2020 - mdpi.com
Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the
cellular defense against toxic and oxidative insults through the expression of genes involved …
cellular defense against toxic and oxidative insults through the expression of genes involved …
NRF2 controls iron homeostasis and ferroptosis through HERC2 and VAMP8
Enhancing the intracellular labile iron pool (LIP) represents a powerful, yet untapped
strategy for driving ferroptotic death of cancer cells. Here, we show that NRF2 maintains iron …
strategy for driving ferroptotic death of cancer cells. Here, we show that NRF2 maintains iron …
Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases
The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2) and its
principal negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 …
principal negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 …
[HTML][HTML] Complex interplay between autophagy and oxidative stress in the development of pulmonary disease
W Ornatowski, Q Lu, M Yegambaram, AE Garcia… - Redox biology, 2020 - Elsevier
The autophagic pathway involves the encapsulation of substrates in double-membraned
vesicles, which are subsequently delivered to the lysosome for enzymatic degradation and …
vesicles, which are subsequently delivered to the lysosome for enzymatic degradation and …
Activators and inhibitors of NRF2: a review of their potential for clinical development
N Robledinos-Antón… - Oxidative medicine …, 2019 - Wiley Online Library
The transcription factor NRF2 (nuclear factor erythroid 2‐related factor 2) triggers the first
line of homeostatic responses against a plethora of environmental or endogenous …
line of homeostatic responses against a plethora of environmental or endogenous …
NRF2 and the Hallmarks of Cancer
The transcription factor NRF2 is the master regulator of the cellular antioxidant response.
Though recognized originally as a target of chemopreventive compounds that help prevent …
Though recognized originally as a target of chemopreventive compounds that help prevent …
[HTML][HTML] Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration
K Kaarniranta, H Uusitalo, J Blasiak… - Progress in retinal and …, 2020 - Elsevier
Oxidative stress-induced damage to the retinal pigment epithelium (RPE) is considered to
be a key factor in age-related macular degeneration (AMD) pathology. RPE cells are …
be a key factor in age-related macular degeneration (AMD) pathology. RPE cells are …
KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential
E Crisman, P Duarte, E Dauden… - Medicinal research …, 2023 - Wiley Online Library
The transcription factor nuclear factor erythroid 2‐related factor 2 (NRF2) is considered the
master regulator of the phase II antioxidant response. It controls a plethora of cytoprotective …
master regulator of the phase II antioxidant response. It controls a plethora of cytoprotective …
Transcription factor NRF2 as a therapeutic target for chronic diseases: a systems medicine approach
Abstract Systems medicine has a mechanism-based rather than a symptom-or organ-based
approach to disease and identifies therapeutic targets in a nonhypothesis-driven manner. In …
approach to disease and identifies therapeutic targets in a nonhypothesis-driven manner. In …