Reactive oxygen species in the tumor microenvironment: an overview
Reactive oxygen species (ROS) are important signaling molecules in cancer. The level of
ROS will determine physiological effects. While high levels of ROS can cause damage to …
ROS will determine physiological effects. While high levels of ROS can cause damage to …
Cross-talk of Brassinosteroid signaling in controlling growth and stress responses
Plants are faced with a barrage of stresses in their environment and must constantly balance
their growth and survival. As such, plants have evolved complex control systems that …
their growth and survival. As such, plants have evolved complex control systems that …
Selective autophagy of BES1 mediated by DSK2 balances plant growth and survival
Plants encounter a variety of stresses and must fine-tune their growth and stress-response
programs to best suit their environment. BES1 functions as a master regulator in the …
programs to best suit their environment. BES1 functions as a master regulator in the …
PBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma
A non-immunogenic tumor microenvironment (TME) is a significant barrier to immune
checkpoint blockade (ICB) response. The impact of Polybromo-1 (PBRM1) on TME and …
checkpoint blockade (ICB) response. The impact of Polybromo-1 (PBRM1) on TME and …
Lactate inhibits ATP6V0d2 expression in tumor-associated macrophages to promote HIF-2α–mediated tumor progression
N Liu, J Luo, D Kuang, S Xu, Y Duan… - The Journal of …, 2019 - Am Soc Clin Investig
Macrophages perform key functions in tissue homeostasis that are influenced by the local
tissue environment. Within the tumor microenvironment, tumor-associated macrophages can …
tissue environment. Within the tumor microenvironment, tumor-associated macrophages can …
Mitochondrial Akt regulation of hypoxic tumor reprogramming
Hypoxia is a universal driver of aggressive tumor behavior, but the underlying mechanisms
are not completely understood. Using a phosphoproteomics screen, we now show that …
are not completely understood. Using a phosphoproteomics screen, we now show that …
VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma
Inactivation of the von Hippel-Lindau (VHL) E3 ubiquitin ligase protein is a hallmark of clear
cell renal cell carcinoma (ccRCC). Identifying how pathways affected by VHL loss contribute …
cell renal cell carcinoma (ccRCC). Identifying how pathways affected by VHL loss contribute …
Autophagy-regulating microRNAs and cancer
Macroautophagy (autophagy herein) is a cellular stress response and a survival pathway
that is responsible for the degradation of long-lived proteins, protein aggregates, as well as …
that is responsible for the degradation of long-lived proteins, protein aggregates, as well as …
d-limonene exhibits antitumor activity by inducing autophagy and apoptosis in lung cancer
X Yu, H Lin, Y Wang, W Lv, S Zhang, Y Qian… - OncoTargets and …, 2018 - Taylor & Francis
Purpose d-limonene is a plant extract with widespread application, and it has been recently
reported to have antiproliferative and proapoptotic effects on cancer cells. However, the …
reported to have antiproliferative and proapoptotic effects on cancer cells. However, the …
Resistance to antiangiogenic therapy is associated with an immunosuppressive tumor microenvironment in metastatic renal cell carcinoma
Renal cell carcinoma (RCC) is an immunogenic and proangiogenic cancer, and
antiangiogenic therapy is the current mainstay of treatment. Patients with RCC develop …
antiangiogenic therapy is the current mainstay of treatment. Patients with RCC develop …