Hypoxia a hallmark of solid tumors makes hypoxic cells radioresistant. On the other
hand, DNA, the main target of anticancer therapy, is not sensitive to the near UV photons …

DNA single-strand breaks (SSB) are the most common form of DNA damage, requiring
repair processes that to initiate must overcome chromatin barriers. The FACT complex …

The electronic structure of DNA is determined by its nucleotide sequence, which is for
instance exploited in molecular electronics. Here we demonstrate that also the DNA strand …

In this work, a set of new potential radiation sensitizers (4-substituted Z-bases: 4XZ, X= F, Cl,
Br, and I) are designed based on the artificial 6-amino-5-nitro-3-(1′-β-D-2 …

In this work, a set of quasi-intrinsic photosensitizers are theoretically proposed based on the
2-amino-8-(1′-β-d-2′-deoxyribofuranosyl)-imidazo [1, 2-α]-1, 3, 5-triazin-4 (8H)-one (P) …

8-Bromoguanosine is generated in vivo as a biomarker for early inflammation. Its formation
and secondary reactions lead to a variety of biological sequelae at inflammation sites, most …

DNA photosensitization is one of the physical processes behind photodynamic therapy
techniques, ie the combined use of photoactive drugs and visible radiation for therapeutical …

Hypoxia, a hallmark of solid tumors, which account for ca. 80% of cancer cases, makes the
cancer cells resistant toward ionizing radiation and as a consequence to radiotherapy, one …

Tumor hypoxia hampers radiotherapy efficacy, necessitating radiosensitizers. Substituted
nucleobases offer advantages as radiosensitizers. They can be incorporated into DNA with …

We report on a joint theoretical and experimental investigation into the electron-induced
fragmentation of 2-chloroadenine, for electrons up to 12 eV. Elastic scattering calculations …