Computational pharmaceutics-A new paradigm of drug delivery

W Wang, Z Ye, H Gao, D Ouyang - Journal of Controlled Release, 2021 - Elsevier
In recent decades pharmaceutics and drug delivery have become increasingly critical in the
pharmaceutical industry due to longer time, higher cost, and less productivity of new …

[HTML][HTML] A Review of Applications of Solid-State Nuclear Magnetic Resonance (ssNMR) for the Analysis of Cyclodextrin-Including Systems

AH Mazurek, Ł Szeleszczuk - International Journal of Molecular Sciences, 2023 - mdpi.com
Cyclodextrins, cyclic oligosaccharides composed of five or more α-D-glucopyranoside units
linked by α-1, 4 glycosidic bonds, are widely used both in their native forms as well as the …

Highly robust quantum mechanics and umbrella sampling studies on inclusion complexes of curcumin and β-cyclodextrin

P Kumar, VK Bhardwaj, R Purohit - Carbohydrate Polymers, 2024 - Elsevier
The poor aqueous solubility of curcumin (CUR) obstructs its wide utilization in
nutraceuticals, cosmetics, and pharmaceutical companies. This study is dedicated to …

Preparation and biophysical characterization of quercetin inclusion complexes with β-cyclodextrin derivatives to be formulated as possible nose-to-brain quercetin …

K Manta, P Papakyriakopoulou… - Molecular …, 2020 - ACS Publications
Quercetin (Que) is a flavonoid associated with high oxygen radical scavenging activity and
potential neuroprotective activity against Alzheimer's disease. Que's oral bioavailability is …

[HTML][HTML] A fruitful century for the scalable synthesis and reactions of biphenyl derivatives: applications and biological aspects

HA Ali, MA Ismail, AEAS Fouda, EA Ghaith - RSC advances, 2023 - pubs.rsc.org
This review provides recent developments in the current status and latest synthetic
methodologies of biphenyl derivatives. Furthermore, this review investigates detailed …

Design, synthesis and biological evaluation of novel fluoro-substituted benzimidazole derivatives with anti-hypertension activities

Z Wu, MB Xia, D Bertsetseg, YH Wang, XL Bao… - Bioorganic …, 2020 - Elsevier
A series of new fluoro-substituted benzimidazole derivatives were designed, synthesized
and pharmacologically evaluated. All the target compounds were characterized by 1 HNMR …

Investigation of praziquantel/cyclodextrin inclusion complexation by NMR and LC-HRMS/MS: mechanism, solubility, chemical stability, and degradation products

TK Špehar, M Pocrnić, D Klarić… - Molecular …, 2021 - ACS Publications
Praziquantel (PZQ) is a biopharmaceutical classification system (BCS) class II anthelmintic
drug characterized by poor solubility and a bitter taste, both of which can be addressed by …

Preparation of indapamide-HP-β-CD and indapamide-PVP nanoparticles by supercritical antisolvent technology: Experimental and DPD simulations

C Lv, S He, G He, X Xiong, C Wang, Y Ren… - The Journal of …, 2024 - Elsevier
The poor aqueous solubility of indapamide (INP) limits its applicability in various biomedical
applications. To overcome this issue, nanosized INP particles (INP-HP-β-CD NPs and INP …

Computational and Spectroscopic Analysis of the Quercetin Encapsulation in (2HP-β-CD) 2 and (2, 6Me-β-CD) 2 Complexes

G Leonis, V Vakali, N Zoupanou, N Georgiou… - Journal of Molecular …, 2023 - Elsevier
Quercetin protects against many diseases due to its radical scavenging and anti-
inflammatory properties. However, due to its poor bioavailability numerous types of …

Exploring Hypertension: The Role of AT1 Receptors, Sartans, and Lipid Bilayers

N Georgiou, E Chontzopoulou, EA Routsi… - ACS …, 2024 - ACS Publications
The rational design of AT1 receptor antagonists represents a pivotal approach in the
development of therapeutic agents targeting cardiovascular pathophysiology. Sartans, a …