Glucocorticoids are potent anti-inflammatory drugs that are used to treat an extraordinary
range of human disease, including COVID-19, underscoring the ongoing importance of …

Innate immunity is the frontline of defense against infections and tissue damage. It is a fast
and semi-specific response involving a myriad of processes essential for protecting the …

Tyrosine kinase inhibitors (TKIs) are the most commonly used targeted therapeutics in clear-
cell renal cell carcinoma (ccRCC); however, drug resistance limits their utility and can lead …

Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer and it
forms highly vascularized tumors. The monocyte endoribonuclease MCPIP1 negatively …

Sepsis is a potentially fatal systemic inflammatory response syndrome caused by infection.
In this study, we evaluated the effects of MCP-induced protein 1 (MCPIP1), a recently …

Inflammation is an organism's physiological response to harmful septic and aseptic stimuli.
This process begins locally through the influx of immune system cells to the damaged tissue …

Rupture or dissection of thoracic aortic aneurysms is still the leading cause of death for
patients diagnosed with Marfan syndrome. Inflammation and matrix digestion regulated by …

MCPIP1, also known as Regnase-1, is a ribonuclease crucial for regulation of stability of
transcripts related to inflammatory processes. Here, we report that MCPIP1 acts as an …

Glioma is the most common primary malignant intracranial tumor in the population, and is
often associated with abundant angiogenesis. However, how angiogenesis is regulated …

The CCCH-type zinc finger (ZnF) containing ZC3H12 ribonucleases are crucial in post-
transcriptional immune homoeostasis with ZC3H12A being the only structurally studied …