In nature, cells reside in tissues subject to complex cell–cell interactions, signals from
extracellular molecules and niche soluble and mechanical signaling. These …

Liver cell types derived from induced pluripotent stem cells (iPSCs) share the potential to
investigate development, toxicity, as well as genetic and infectious disease in ways currently …

Human liver cancer research currently lacks in vitro models that can faithfully recapitulate
the pathophysiology of the original tumor. We recently described a novel, near-physiological …

Type 2 diabetes mellitus (T2DM) is a systematic multi‐organ metabolic disease, which is
characterized by the dynamic interplay among different organs. The increasing incidence of …

The rising interest in human induced pluripotent stem cell (hiPSC)-derived organoid culture
has stemmed from the manipulation of various combinations of directed multi-lineage …

Abstract Three-dimensional (3D) cultures use the property of some cells to self-organize in
matrices and generate structures that can be programmed to represent an organ or a …

Epithelial cell loss alters a tissue's optimal function and awakens evolutionarily adapted
healing mechanisms to reestablish homeostasis. Although adult mammalian organs have a …

Organoids are a new class of biological model systems that have garnered significant
interest in the life sciences. When provided with the proper 3D matrix and biochemical …

Diabetes mellitus is a multifactorial disease affecting increasing numbers of patients
worldwide. Progression to insulin-dependent diabetes mellitus is characterized by the loss …

Pancreatic ductal adenocarcinoma is one of the most aggressive forms of cancer, and the
third leading cause of cancer-related mortality in the United States. Although important …