Regulation and role of fungal secondary metabolites

J Macheleidt, DJ Mattern, J Fischer… - Annual review of …, 2016 - annualreviews.org
Fungi have the capability to produce a tremendous number of so-called secondary
metabolites, which possess a multitude of functions, eg, communication signals during …

The Aspergillus fumigatus cell wall integrity signaling pathway: drug target, compensatory pathways, and virulence

V Valiante, J Macheleidt, M Föge… - Frontiers in …, 2015 - frontiersin.org
Aspergillus fumigatus is the most important airborne fungal pathogen, causing severe
infections with invasive growth in immunocompromised patients. The fungal cell wall (CW) …

Trichophyton rubrum azole resistance mediated by a new ABC transporter, TruMDR3

M Monod, M Feuermann, K Salamin… - Antimicrobial agents …, 2019 - Am Soc Microbiol
The mechanisms of terbinafine resistance in a set of clinical isolates of Trichophyton rubrum
have been studied recently. Of these isolates, TIMM20092 also showed reduced sensitivity …

A call to arms: Mustering secondary metabolites for success and survival of an opportunistic pathogen

N Raffa, NP Keller - PLoS pathogens, 2019 - journals.plos.org
Aspergillus fumigatus is a ubiquitous saprophytic mold able to grow on a diversity of material
ranging from decayed organic matter in the environment to space station cupolas [1]. Yet this …

Harnessing diverse transcriptional regulators for natural product discovery in fungi

HN Lyu, HW Liu, NP Keller, WB Yin - Natural Product Reports, 2020 - pubs.rsc.org
Covering: Up to March 2019 Secondary metabolites (SMs) are chemical entities produced
by organisms in response to environmental stimuli and as a defense against biological …

Recent advances in the genome mining of Aspergillus secondary metabolites (covering 2012–2018)

J Romsdahl, CCC Wang - Medchemcomm, 2019 - pubs.rsc.org
Secondary metabolites (SMs) produced by filamentous fungi possess diverse bioactivities
that make them excellent drug candidates. Whole genome sequencing has revealed that …

Genome-based engineering of ligninolytic enzymes in fungi

MD Asemoloye, MA Marchisio, VK Gupta… - Microbial cell …, 2021 - Springer
Background Many fungi grow as saprobic organisms and obtain nutrients from a wide range
of dead organic materials. Among saprobes, fungal species that grow on wood or in polluted …

Inducible promoters and functional genomic approaches for the genetic engineering of filamentous fungi

J Kluge, D Terfehr, U Kück - Applied microbiology and biotechnology, 2018 - Springer
In industry, filamentous fungi have a prominent position as producers of economically
relevant primary or secondary metabolites. Particularly, the advent of genetic engineering of …

Fungal BGCs for production of secondary metabolites: main types, central roles in strain improvement, and regulation according to the piano principle

AA Zhgun - International Journal of Molecular Sciences, 2023 - mdpi.com
Filamentous fungi are one of the most important producers of secondary metabolites. Some
of them can have a toxic effect on the human body, leading to diseases. On the other hand …

Extrolites of Aspergillus fumigatus and Other Pathogenic Species in Aspergillus Section Fumigati

JC Frisvad, TO Larsen - Frontiers in Microbiology, 2016 - frontiersin.org
Aspergillus fumigatus is an important opportunistic human pathogen known for its
production of a large array of extrolites. Up to 63 species have been described in Aspergillus …