Ruptured and intact plasma membranes are classically considered as hallmarks of necrotic
and apoptotic cell death, respectively. As such, apoptosis is usually considered a non …

The molecular details of mammalian stress-activated signal transduction pathways have
only begun to be dissected. This, despite the fact that the impact of these pathways on the …

In the final stages of apoptosis, apoptotic cells can generate a variety of membrane-bound
vesicles known as apoptotic extracellular vesicles (ApoEVs). Apoptotic bodies (ApoBDs), a …

▪ Abstract Apoptosis is a genetically programmed, morphologically distinct form of cell death
that can be triggered by a variety of physiological and pathological stimuli. Studies …

The concept of apoptotic cell death as an essential part of the development and life of
complex organisms has been devised in different situations and tested from various angles …

Caspases play an essential role during apoptotic cell death. These enzymes define a new
class of cysteine proteases and comprise a multi-gene family with more than a dozen distinct …

Apoptotic cell death is executed by the caspase-mediated cleavage of various vital proteins.
Elucidating the consequences of this endoproteolytic cleavage is crucial for our …

Increased phosphorylation of myosin light chain (MLC) is necessary for the dynamic
membrane blebbing that is observed at the onset of apoptosis. Here we identify ROCK I, an …

▪ Abstract The p21-activated kinases (PAKs) 1–3 are serine/threonine protein kinases whose
activity is stimulated by the binding of active Rac and Cdc42 GTPases. Our understanding of …

▪ Abstract Four members of the tumor necrosis factor (TNF) ligand family, TNF-α, LT-α, LT-β,
and LIGHT, interact with four receptors of the TNF/nerve growth factor family, the p55 TNF …