The heart is adapted to utilize all classes of substrates to meet the high-energy demand, and
it tightly regulates its substrate utilization in response to environmental changes. Although …

Increasing evidence demonstrates that advanced glycation end products (AGEs) play a
pivotal role in the development and progression of diabetic heart failure, although there are …

In many cells and specially in muscle, mitochondria form elongated filaments or a branched
reticulum. We show that Mfn2 (mitofusin 2), a mitochondrial membrane protein that …

Resistance to the stimulatory effects of insulin on glucose utilization is a key feature of type 2
diabetes, obesity, and the metabolic syndrome. Recent studies suggest that insulin …

Monosaccharides enter cells by slow translipid bilayer diffusion by rapid, protein-mediated,
cation-dependent cotransport and by rapid, protein-mediated equilibrative transport. This …

The heart is a unique organ in many ways. It consists of specialized muscle cells
(cardiomyocytes), which are adapted to contract constantly in a coordinated fashion. This is …

Of all cells, human erythrocytes express the highest level of the Glut1 glucose transporter.
However, the regulation and function of Glut1 during erythropoiesis are not known. Here, we …

Proper heart function relies on high efficiency of energy conversion. Mitochondrial oxygen-
dependent processes transfer most of the chemical energy from metabolic substrates into …

Myocardial ischemia occurs for a mismatch between blood flow and metabolic requirements,
when the rate of oxygen and metabolic substrates delivery to the myocardium is insufficient …

El embarazo es una etapa de vital importancia, donde tienen lugar múltiples procesos
hiperplásicos, hipertróficos, de adaptación metabólica y de preparación para la vida …