The hygiene hypothesis in autoimmunity: the role of pathogens and commensals

JF Bach - Nature Reviews Immunology, 2018 - nature.com
The incidence of autoimmune diseases has been steadily rising. Concomitantly, the
incidence of most infectious diseases has declined. This observation gave rise to the …

[HTML][HTML] Microbial view of central nervous system autoimmunity

K Berer, G Krishnamoorthy - FEBS letters, 2014 - Elsevier
Not much is known about the initial events leading to the development of the central nervous
system (CNS)-specific autoimmune disorder Multiple Sclerosis (MS). Environmental factors …

The EPIIC hypothesis: intrapartum effects on the neonatal epigenome and consequent health outcomes

HG Dahlen, HP Kennedy, CM Anderson, AF Bell… - Medical hypotheses, 2013 - Elsevier
There are many published studies about the epigenetic effects of the prenatal and infant
periods on health outcomes. However, there is very little knowledge regarding the effects of …

Differential impact of environmental factors on systemic and localized autoimmunity

H Touil, K Mounts, PL De Jager - Frontiers in immunology, 2023 - frontiersin.org
The influence of environmental factors on the development of autoimmune disease is being
broadly investigated to better understand the multifactorial nature of autoimmune …

Pregnancy with multiple sclerosis

S Vukusic, L Michel, S Leguy, C Lebrun-Frenay - Revue Neurologique, 2021 - Elsevier
Multiple sclerosis (MS) is usually diagnosed between twenty and forty years of age, when
people often plan to have children. A lot has been said about the effect of pregnancy on the …

Developmental programming of aging trajectory

A Vaiserman, A Koliada, O Lushchak - Ageing Research Reviews, 2018 - Elsevier
There is accumulating evidence that aging phenotype and longevity may be
developmentally programmed. Main mechanisms linking developmental conditions to later …

Host–microbiota interplay in mediating immune disorders

KM Felix, S Tahsin, HJJ Wu - Annals of the New York Academy …, 2018 - Wiley Online Library
To maintain health, the immune system must maintain a delicate balance between
eliminating invading pathogens and avoiding immune disorders such as autoimmunity and …

Maternal and perinatal exposures are associated with risk for pediatric-onset multiple sclerosis

JS Graves, T Chitnis, B Weinstock-Guttman… - …, 2017 - publications.aap.org
OBJECTIVE: To determine if prenatal, pregnancy, or postpartum-related environmental
factors are associated with multiple sclerosis (MS) risk in children. METHODS: This is a case …

Childbirth delivery mode and the risk of multiple sclerosis: a prospective population-based study

A Kapali, AK Daltveit, KM Myhr, K Bjornevik… - Journal of Neurology …, 2024 - jnnp.bmj.com
Background Caesarean section (CS) may affect the risk of developing multiple sclerosis
(MS) in the offspring, possibly through changes in gut microbiota composition, but findings …

Pediatric multiple sclerosis: genes, environment, and a comprehensive therapeutic approach

R Cappa, L Theroux, JN Brenton - Pediatric neurology, 2017 - Elsevier
Background Pediatric multiple sclerosis is an increasingly recognized and studied disorder
that accounts for 3% to 10% of all patients with multiple sclerosis. The risk for pediatric …