Target based chemotherapeutic advancement of ruthenium complexes

BK Kundu, S Mukhopadhyay - Coordination Chemistry Reviews, 2021 - Elsevier
Over the last few years, great emphasis has been given to develop ruthenium complexes to
act as target specified chemotherapeutic agents. Indeed, there are few reviews available …

Exploring the potential of metallodrugs as chemotherapeutics for triple negative breast cancer

N Nayeem, M Contel - Chemistry–A European Journal, 2021 - Wiley Online Library
This review focuses on studies of coordination and organometallic compounds as potential
chemotherapeutics against triple negative breast cancer (TNBC) which has one of the …

Increasing anticancer activity with phosphine ligation in zwitterionic half-sandwich iridium (III), rhodium (III), and ruthenium (II) complexes

X Hu, L Guo, M Liu, Q Zhang, Y Gong, M Sun… - Inorganic …, 2022 - ACS Publications
The synthesis and biological assessment of neutral or cationic platinum group metal-based
anticancer complexes have been extremely studied, whereas there are few reports on the …

Zebrafish as an emerging model system in the global south: two decades of research in Brazil

NSS Trigueiro, A Canedo, DLS Braga, AC Luchiari… - Zebrafish, 2020 - liebertpub.com
The zebrafish (Danio rerio) is an emerging model system in several research areas
worldwide, especially in the Global South. In this context, the present study revised the …

“Half-Sandwich” Ruthenium Complexes with Alizarin as Anticancer Agents: In Vitro and In Vivo Studies

JH de Araujo-Neto, APM Guedes, CM Leite… - Inorganic …, 2023 - ACS Publications
Upon exploration of the chemistry of the combination of ruthenium/arene with anthraquinone
alizarin (L), three new complexes with the general formulas [Ru (L) Cl (η6-p …

Dual-Action Ru (II) Complexes with Bulky π-Expansive Ligands: Phototoxicity without DNA Intercalation

NP Toupin, S Nadella, SJ Steinke, C Turro… - Inorganic …, 2020 - ACS Publications
We report the synthesis and photochemical and biological characterization of Ru (II)
complexes containing π-expansive ligands derived from dimethylbenzo [i] dipyrido [3, 2-a …

Lapachol in the design of a new ruthenium (II)-diphosphine complex as a promising anticancer metallodrug

KM Oliveira, J Honorato, FC Demidoff… - Journal of Inorganic …, 2021 - Elsevier
The preparation of two new Ru (II)/diphosphine complexes containing Lapachol (Lap) and
Lawsone (Law):(1)[Ru (Lap)(dppm) 2] PF 6 and (2)[Ru (Law)(dppm) 2] PF 6, where dppm …

Exploring the cytotoxicity of dinuclear Ru (ii) p-cymene complexes appended N, N′-bis (4-substituted benzoyl) hydrazines: insights into the mechanism of apoptotic …

A Abirami, U Devan, R Ramesh, AAJ Velanganni… - Dalton …, 2024 - pubs.rsc.org
Cancer is a perilous life-threatening disease, and attempts are constantly being made to
create multinuclear transition metal complexes that could lead to the development of …

Cytotoxic activity of Ru (II)/DPEPhos/N, S-mercapto complexes (DPEPhos= bis-[(2-diphenylphosphino) phenyl] ether)

GF Grawe, KM Oliveira, CM Leite, TD de Oliveira… - Journal of Inorganic …, 2023 - Elsevier
We report here on three new ruthenium (II) complexes,[Ru (DPEPhos)(mtz)(bipy)] PF 6
(Ru1),[Ru (DPEPhos)(mmi)(bipy)] PF 6 (Ru2) and [Ru (DPEPhos)(dmp)(bipy)] PF 6 (Ru3) …

Discovery of ruthenium (II) metallocompound and olaparib synergy for cancer combination therapy

NA Yusoh, PR Tiley, SD James, SN Harun… - Journal of Medicinal …, 2023 - ACS Publications
Synergistic drug combinations can extend the use of poly (ADP-ribose) polymerase
inhibitors (PARPi) such as Olaparib to BRCA-proficient tumors and overcome acquired or de …