The advent of single-molecule, long-read sequencing (LRS) technologies by Oxford
Nanopore Technologies and Pacific Biosciences has revolutionized genomics …

Accurately quantifying the functional consequences of noncoding mosaic variants requires
the pairing of DNA sequences with both accessible and closed chromatin architectures …

Resolving the molecular basis of a Mendelian condition remains challenging owing to the
diverse mechanisms by which genetic variants cause disease. To address this, we …

Chromosome segregation relies on kinetochores that assemble on specialized centromeric
chromatin containing a histone H3 variant. In budding yeast, a single centromeric …

The focal attachment of the kinetochore to the centromere is essential for genome
maintenance, yet the highly repetitive nature of satellite regional centromeres, such as those …

We apply a single-molecule chromatin fiber sequencing (Fiber-seq) protocol designed for
amplification-free cell-type-specific mapping of the regulatory architecture at nucleosome …

Since their initial discovery in maize, transposable elements (TEs) have emerged as being
integral to the evolution of maize, accounting for 80% of its genome. However, the repetitive …