RagGTPases (Rags) play an essential role in the regulation of cell metabolism by controlling
the activities of both mechanistic target of rapamycin complex 1 (mTORC1) and …

Metabolic homeostasis and the ability to link energy supply to demand are essential
requirements for all living cells to grow and proliferate. Key to metabolic homeostasis in all …

Nutrient signaling converges on mTORC1, which, in turn, orchestrates a physiological
cellular response. A key determinant of mTORC1 activity is its shuttling between the …

Tuberous sclerosis complex (TSC) is a rare multisystem disorder caused by heterozygous
loss-of-function pathogenic variants in the tumour suppressor genes TSC1 and TSC2 …

The advent of high‐dimensional imaging offers new opportunities to molecularly
characterize diagnostic cells in disorders that have previously relied on histopathological …

Background Patients with tuberous sclerosis complex (TSC) develop renal cysts and/or
angiomyolipomas (AMLs) due to inactive mutations of either TSC1 or TSC2 and …

Lymphangioleiomyomatosis (LAM) is a rare, progressive, and poor-prognosis systemic
disorder that primarily affects women of reproductive age, with a higher prevalence among …

Simple Summary The characterization of molecular alterations is continuously gaining
relevance in pathology as it can contribute to explaining tumors' pathogenesis and address …

Pathogenic mutations in the genes associated with tuberous sclerosis complex (TSC)/mTOR
pathway are linked to histologically diverse renal cell neoplasms, including eosinophilic …

The mammalian target of Rapamycin complex 1 (mTORC1) is a serine/threonine kinase that
couples nutrient and growth factor signaling to the cellular control of metabolism and plays a …