Over the past decade, melanoma has led the field in new cancer treatments, with impressive
gains in on-treatment survival but more modest improvements in overall survival. Melanoma …

The mechanisms by which the pigment melanin is transferred from melanocytes and
processed within keratinocytes to achieve skin pigmentation remain ill-characterized …

Mechanical forces (extracellular matrix stiffness, vascular shear stress, and muscle
stretching) reaching the plasma membrane (PM) determine cell behavior. Caveolae are PM …

Caveolae are 70–100 nm diameter plasma membrane invaginations found in abundance in
adipocytes, endothelial cells, myocytes, and fibroblasts. Their bulb-shaped membrane …

The evolutionarily ancient methoxyindoleamine, melatonin, has long perplexed investigators
by its versatility of functions and mechanisms of action, which include the regulation of …

Human skin and hair pigmentation play important roles in social behavior but also in
photoprotection from the harmful effects of ultraviolet light. The main pigments in mammalian …

Skin pigmentation ensures efficient photoprotection and relies on the pigment melanin,
which is produced by epidermal melanocytes and transferred to surrounding keratinocytes …

Melanocytes, which originate from the neuroectoderm, are specialized cells responsible for
producing pigments and possessing a dendritic morphology. These cells migrate to the …

Cytokinetic abscission leads to the physical cut of the intercellular bridge (ICB) connecting
the daughter cells and concludes cell division. In different animal cells, it is well established …

During cytokinesis, the intercellular bridge (ICB) connecting the daughter cells experiences
pulling forces, which delay abscission by preventing the assembly of the ESCRT scission …