The breadth of structure and function displayed by the molecules of biology is remarkable.
Considering that there are only three major biopolymer backbones (proteins, ribonucleic …

In recent years, our understanding of protein structure and function has advanced rapidly,
providing a mechanistic understanding of a wide variety of biological processes. As an …

Nature relies on large molecules to carry out sophisticated chemical operations, such as
catalysis, tight and specific binding, directed flow of electrons, or controlled crystallization of …

Chemists have long sought to extrapolate the power of biological catalysis and recognition
to synthetic systems. These efforts have focused largely on low molecular weight catalysts …

The β‐hexapeptide (H‐β‐HVal‐β‐HAla‐β‐HLeu) 2‐OH (2) was prepared from the
component l‐β‐amino acids by conventional peptide synthesis, including fragment coupling …

Proteins and RNA are unique among known polymers in their ability to adopt compact and
well-defined folding patterns. These two biopolymers can perform complex chemical …

The remarkable complexity of globular protein structures was first revealed about half a
century ago, when the crystal structure of myoglobin was determined at 2.4 Å. 1 In the …

β-Peptides are a class of polyamides that have been demonstrated to adopt a variety of
helical conformations. Recently, a series of amphiphilic L+ 2 helical β-peptides were …

Synthetic protocols and circular dichroism (CD) spectra are reported for a series of
oligomers of (R, R)-trans-2-aminocyclopentanecarboxylic acid (trans-ACPC). The two …

The treatment of bacterial infections is hindered by the presence of biofilms and
metabolically inactive persisters. Here, we report the synthesis of an enantiomeric block co …