Cell cycle proteins as promising targets in cancer therapy
T Otto, P Sicinski - Nature Reviews Cancer, 2017 - nature.com
Cancer is characterized by uncontrolled tumour cell proliferation resulting from aberrant
activity of various cell cycle proteins. Therefore, cell cycle regulators are considered …
activity of various cell cycle proteins. Therefore, cell cycle regulators are considered …
The functional diversity of Aurora kinases: a comprehensive review
E Willems, M Dedobbeleer, M Digregorio, A Lombard… - Cell division, 2018 - Springer
Aurora kinases are serine/threonine kinases essential for the onset and progression of
mitosis. Aurora members share a similar protein structure and kinase activity, but exhibit …
mitosis. Aurora members share a similar protein structure and kinase activity, but exhibit …
[HTML][HTML] Aurora kinases: novel therapy targets in cancers
A Tang, K Gao, L Chu, R Zhang, J Yang, J Zheng - Oncotarget, 2017 - ncbi.nlm.nih.gov
Aurora kinases, a family of serine/threonine kinases, consisting of Aurora A (AURKA),
Aurora B (AURKB) and Aurora C (AURKC), are essential kinases for cell division via …
Aurora B (AURKB) and Aurora C (AURKC), are essential kinases for cell division via …
Potential therapeutic targets of quercetin, a plant flavonol, and its role in the therapy of various types of cancer through the modulation of various cell signaling …
Polyphenolic flavonoids are considered natural, non-toxic chemopreventers, which are most
commonly derived from plants, fruits, and vegetables. Most of these polyphenolics exhibit …
commonly derived from plants, fruits, and vegetables. Most of these polyphenolics exhibit …
Plk1 overexpression induces chromosomal instability and suppresses tumor development
G de Cárcer, SV Venkateswaran, L Salgueiro… - Nature …, 2018 - nature.com
Abstract Polo-like kinase 1 (Plk1) is overexpressed in a wide spectrum of human tumors,
being frequently considered as an oncogene and an attractive cancer target. However, its …
being frequently considered as an oncogene and an attractive cancer target. However, its …
Clonal selection of stable aneuploidies in progenitor cells drives high-prevalence tumorigenesis
M Trakala, M Aggarwal, C Sniffen… - Genes & …, 2021 - genesdev.cshlp.org
Chromosome gains and losses are a frequent feature of human cancers. However, how
these aberrations can outweigh the detrimental effects of aneuploidy remains unclear. An …
these aberrations can outweigh the detrimental effects of aneuploidy remains unclear. An …
Aurora-A kinase as a promising therapeutic target in cancer
Mammalian Aurora family of serine/threonine kinases are master regulators of mitotic
progression and are frequently overexpressed in human cancers. Among the three …
progression and are frequently overexpressed in human cancers. Among the three …
Aurora A kinase is a priority pharmaceutical target for the treatment of cancers
AP Damodaran, L Vaufrey, O Gavard… - Trends in pharmacological …, 2017 - cell.com
Aurora kinases control multiple events during cell cycle progression and are essential for
mitotic and meiotic bipolar spindle assembly and function. There are three Aurora kinases in …
mitotic and meiotic bipolar spindle assembly and function. There are three Aurora kinases in …
[HTML][HTML] AURKB promotes gastric cancer progression via activation of CCND1 expression
Aurora kinase B (AURKB) triggers the phosphorylation of serine 10 on histone H3
(H3S10ph), which is important for chromosome condensation and cytokinesis during mitosis …
(H3S10ph), which is important for chromosome condensation and cytokinesis during mitosis …