Cytochromes P450 (CYPs) belong to the superfamily of heme b containing
monooxygenases with currently more than 21,000 members. These enzymes accept a vast …

Screen printing technology provides a cheap and easy means to fabricate disposable
electrochemical devices in bulk quantities which are used for rapid, low-cost, on-site, real …

Cytochrome P450s (CYPs) are a large family of heme-containing monooxygenase enzymes
involved in the first-pass metabolism of drugs and foreign chemicals in the body. CYP …

Drug metabolism in human liver is a process involving many different enzymes. Among
them, a number of cytochromes P450 isoforms catalyze the oxidation of most of the drugs …

Microfluidics has developed as a powerful tool for cell-biology research due to its intrinsic
advantages. Recently, considerable progress was made in microfluidic technology for cell …

Assessment of drug candidate's potential to inhibit cytochrome P450 (CYP) enzymes
remains crucial in pharmaceutical drug discovery and development. Both direct and time …

This review covers the current state of knowledge regarding artificial fusion constructs of
cytochrome P 450 enzymes in which the activity of the catalytic heme is driven by reductases …

Electrochemical biosensors that combine high selectivity of biochemical affinity with precise
electrochemical detection are one of the most necessary and powerful tools for assessing …

It is highly advantageous to devise an in vitro platform that can predict the complexity of an in
vivo system. The first step of this process is the identification of a xenobiotic whose …

Prediction of oxidative drug metabolism at the early stages of drug discovery and
development requires fast and accurate analytical techniques to mimic the in vivo oxidation …