DNA methylation represents a form of genome annotation that mediates gene repression by
serving as a maintainable mark that can be used to reconstruct silent chromatin following …

Progress in diverse scientific fields has been realized partly by the continued refinement of
mammalian gene expression vectors. A growing understanding of biological processes now …

THE major active ingredient of marijuana, Δ9-tetrahydrocannabi-nol (Δ9-THC), has been
used as a psychoactive agent for thousands of years. Marijuana, and Δ9-THC, also exert a …

Thiazolidinedione derivatives are antidiabetic agents that increase the insulin sensitivity of
target tissues in animal models of non-insulin-dependent diabetes mellitus. In vitro …

Hypoxia-inducible factor 1 (HIF-1) is a basic helix-loop-helix transcription factor which is
expressed when mammalian cells are subjected to hypoxia and which activates …

Tumor necrosis factor α (TNFα) is a potent immunomodulator and proinflammatory cytokine
that has been implicated in the pathogenesis of autoimmune and infectious diseases. For …

Cytotoxic T lymphocytes (CTLs) specific for conserved viral antigens can respond to different
strains of virus, in contrast to antibodies, which are generally strain-specific. The generation …

The human progesterone receptor (hPR) cDNA, synthesized from T47D breast cancer cells,
and the hPR gene 5′‐flanking region were cloned and sequenced. Comparison of the …

Steroid hormones exert profound effects on differentiation, development, and homeostasis in
higher eukaryotes through interactions with nuclear receptors. We describe a novel orphan …

The cytochrome P-450 monooxygenase 3A4 (CYP3A4) is responsible for the oxidative
metabolism of a wide variety of xenobiotics including an estimated 60% of all clinically used …