Many cancer type-specific anticancer agents have been developed and significant
advances have been made toward precision medicine in cancer treatment. However …

DNA topoisomerases are enzymes that control the topology of DNA in all cells. There are
two types, I and II, classified according to whether they make transient single-or double …

Type IIA DNA topoisomerases play multiple essential roles in the management of higher-
order DNA structure, including modulation of topological state, chromosome segregation …

Ribosome assembly is required for cell growth in all organisms. Classic in vitro work in
bacteria has led to a detailed understanding of the biophysical, thermodynamic, and …

Hsp90 is a homodimeric ATP-dependent molecular chaperone that remodels its substrate
'client'proteins, facilitating their folding and activating them for biological function. Despite …

DNA topos (topoisomerases) are complex, multisubunit enzymes that remodel DNA
topology. Members of the type II topo family function by passing one segment of duplex DNA …

The level of negative DNA supercoiling of the Escherichia coli chromosome is tightly
regulated in the cell and influences many DNA metabolic processes including DNA …

Type IIA and type IIB topoisomerases each possess the ability to pass one DNA duplex
through another in an ATP‐dependent manner. The role of ATP in the strand passage …

Type II DNA topoisomerases (topos) catalyse changes in DNA topology by passing one
double-stranded DNA segment through another. This reaction is essential to processes such …

Beyond their requisite functions in many critical DNA processes, the bacterial type II
topoisomerases, gyrase and topoisomerase IV, are the targets of fluoroquinolone …