With the rapid expansion of aging biology research, the identification and evaluation of
longevity interventions in humans have become key goals of this field. Biomarkers of aging …

Middle age has historically been an understudied period of life compared to older age, when
cognitive and brain health decline are most pronounced, but the scope for intervention may …

Quantifying aging rate is important for evaluating age-associated decline and mortality. A
blood single-cell RNA sequencing dataset for seven supercentenarians (SCs) was recently …

Aging is characterized by a decline in tissue function, but the underlying changes at cellular
resolution across the organism remain unclear. Here, we present the Aging Fly Cell Atlas, a …

Conventional methods fall short in unraveling the dynamics of rare cell types related to
aging and diseases. Here we introduce EasySci, an advanced single-cell combinatorial …

The conserved p38 MAPK family is activated by phosphorylation during stress responses
and inactivated by phosphatases. C. elegans PMK-1 p38 MAPK initiates innate immune …

Aging is a complex and multifactorial process that increases the risk of various age-related
diseases and there are many aging clocks that can accurately predict chronological age …

Whole-transcriptome spatial profiling of genes at single-cell resolution remains a challenge.
To address this limitation, spatial gene expression prediction methods have been developed …

Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …

Aging is a major risk factor for many diseases. Accurate methods for predicting age in
specific cell types are essential to understand the heterogeneity of aging and to assess …