Bioengineered nanogels for cancer immunotherapy

X Ma, SJ Li, Y Liu, T Zhang, P Xue, Y Kang… - Chemical Society …, 2022 - pubs.rsc.org
Recent years have witnessed increasingly rapid advances in nanocarrier-based
biomedicine aimed at improving treatment paradigms for cancer. Nanogels serve as …

Structurally dynamic hydrogels for biomedical applications: pursuing a fine balance between macroscopic stability and microscopic dynamics

K Zhang, Q Feng, Z Fang, L Gu, L Bian - Chemical Reviews, 2021 - ACS Publications
Owing to their unique chemical and physical properties, hydrogels are attracting increasing
attention in both basic and translational biomedical studies. Although the classical hydrogels …

Activatable polymer nanoagonist for second near-infrared photothermal immunotherapy of cancer

Y Jiang, J Huang, C Xu, K Pu - Nature communications, 2021 - nature.com
Nanomedicine in combination with immunotherapy offers opportunities to treat cancer in a
safe and effective manner; however, remote control of immune response with spatiotemporal …

Single-dose injectable nanovaccine-in-hydrogel for robust immunotherapy of large tumors with abscopal effect

F Cheng, T Su, S Zhou, X Liu, S Yang, S Lin, W Guo… - Science …, 2023 - science.org
Current cancer immunotherapy [eg, immune checkpoint blockade (ICB)] only benefits small
subsets of patients, largely due to immunosuppressive tumor microenvironment (TME). In …

Enzyme-instructed peptide assembly favored by preorganization for cancer cell membrane engineering

Y Ding, D Zheng, L Xie, X Zhang, Z Zhang… - Journal of the …, 2023 - ACS Publications
Innovative methods for engineering cancer cell membranes promise to manipulate cell–cell
interactions and boost cell-based cancer therapeutics. Here, we illustrate an in situ …

Tumour sensitization via the extended intratumoural release of a STING agonist and camptothecin from a self-assembled hydrogel

F Wang, H Su, D Xu, W Dai, W Zhang, Z Wang… - Nature biomedical …, 2020 - nature.com
Tumours with an immunosuppressive microenvironment respond poorly to therapy.
Activation of the stimulator of interferon genes (STING) pathway can enhance intratumoural …

Responsive biomaterials: optimizing control of cancer immunotherapy

L Xue, AS Thatte, D Mai, RM Haley, N Gong… - Nature Reviews …, 2024 - nature.com
Immunotherapy has emerged as an eminent and effective modality in the treatment of
cancer. However, current cancer immunotherapies lack spatial and temporal control …

Self-assembling paclitaxel-mediated stimulation of tumor-associated macrophages for postoperative treatment of glioblastoma

F Wang, Q Huang, H Su, M Sun… - Proceedings of the …, 2023 - National Acad Sciences
The unique cancer-associated immunosuppression in brain, combined with a paucity of
infiltrating T cells, contributes to the low response rate and poor treatment outcomes of T cell …

Peptide-based supramolecular hydrogels for local drug delivery

Z Zhang, S Ai, Z Yang, X Li - Advanced Drug Delivery Reviews, 2021 - Elsevier
Peptide-based supramolecular hydrogels have shown great promise as drug delivery
systems (DDSs) because of their excellent biocompatibility, biodegradability, biological …

Designing hydrogels for immunomodulation in cancer therapy and regenerative medicine

Z Zhang, C He, X Chen - Advanced Materials, 2024 - Wiley Online Library
The immune system not only acts as a defense against pathogen and cancer cells, but also
plays an important role in homeostasis and tissue regeneration. Targeting immune systems …