Therapeutic strategies for COVID-19: progress and lessons learned

G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

Nanobodies: robust miniprotein binders in biomedicine

JYJ Kim, Z Sang, Y Xiang, Z Shen, Y Shi - Advanced Drug Delivery …, 2023 - Elsevier
Variable domains of heavy chain-only antibodies (VHH), also known as nanobodies (Nbs),
are monomeric antigen-binding domains derived from the camelid heavy chain-only …

Camelid single-domain antibodies: promises and challenges as lifesaving treatments

M Arbabi-Ghahroudi - International journal of molecular sciences, 2022 - mdpi.com
Since the discovery of camelid heavy-chain antibodies in 1993, there has been tremendous
excitement for these antibody domains (VHHs/sdAbs/nanobodies) as research tools …

Interaction of SARS-CoV-2 with host cells and antibodies: experiment and simulation

H Nguyen, HL Nguyen, PD Lan, NQ Thai… - Chemical Society …, 2023 - pubs.rsc.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the devastating global COVID-19 pandemic announced by WHO in March 2020. Through …

Applications of the phage display technology in molecular biology, biotechnology and medicine

K Pierzynowska, J Morcinek-Orłowska… - Critical Reviews in …, 2024 - Taylor & Francis
The phage display technology is based on the presentation of peptide sequences on the
surface of virions of bacteriophages. Its development led to creation of sophisticated systems …

Structural insights into the design of synthetic nanobody libraries

MS Valdés-Tresanco, A Molina-Zapata, AG Pose… - Molecules, 2022 - mdpi.com
Single domain antibodies from camelids, or nanobodies, are a unique class of antibody
fragments with several advantageous characteristics: small monomeric size, high stability …

A bispecific antibody targeting RBD and S2 potently neutralizes SARS-CoV-2 Omicron and other variants of concern

M Yuan, X Chen, Y Zhu, X Dong, Y Liu, Z Qian… - Journal of …, 2022 - Am Soc Microbiol
Emerging severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) variants,
especially the Omicron variant, have impaired the efficacy of existing vaccines and most …

The potential of nanobodies for COVID-19 diagnostics and therapeutics

DB Naidoo, AA Chuturgoon - Molecular Diagnosis & Therapy, 2023 - Springer
The infectious severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the
causative agent for coronavirus disease 2019 (COVID-19). Globally, there have been …

COVID-19 impedimetric biosensor based on polypyrrole nanotubes, nickel hydroxide and VHH antibody fragment: specific, sensitive, and rapid viral detection in saliva …

A Santos, APM de Souza Brandão… - Materials Today …, 2023 - Elsevier
SARS-CoV-2 rapid spread required urgent, accurate, and prompt diagnosis to control the
virus dissemination and pandemic management. Several sensors were developed using …

Optimized intramuscular immunization with VSV-vectored spike protein triggers a superior immune response to SARS-CoV-2

A Taddeo, IB Veiga, C Devisme, R Boss, P Plattet… - NPJ vaccines, 2022 - nature.com
Immunization with vesicular stomatitis virus (VSV)-vectored COVID-19 vaccine candidates
expressing the SARS-CoV-2 spike protein in place of the VSV glycoprotein relies implicitly …