Contemporary genetic research has provided evidences that angioedema represents a
diverse family of disorders related to kinin metabolism, with a much greater genetic …

Angioedema (AE) occurring during ACE inhibitor therapy (ACEi-AE) is a rare complication
involving between 0.1 and 0.7% of treated patients. AE can also complicate other …

Historically, the first described effect of an angiotensin converting enzyme (ACE) inhibitor
was an increased activity of bradykinin, one of the substrates of ACE. However, in the …

Angio‐oedema (AE) is a known adverse effect of angiotensin converting enzyme inhibitor
(ACE‐I) therapy. Over the past several decades, evidence of failure to diagnose this …

Background Angioedema is a rare adverse effect of angiotensin-converting enzyme (ACE)
inhibitors, which occurs more commonly in women and black Americans. Angioedema is …

Aim: Angioedema and cough are the two most important adverse effects of ACE inhibitors
(ACEIs). Evidence exists that ACEI-related angioedema/cough is partly genetically …

Objective To provide an update on the molecular mechanisms of hereditary angioedema
(HAE). Data Sources MEDLINE and PubMed databases were searched to identify pertinent …

Endogenous kinins are important vasoactive peptides whose effects are mediated by two G-
Protein-coupled receptors (R), named B2R (constitutive) and B1R (inducible). They are …

Genes control biological processes such as muscle, cartilage and bone formation, muscle
energy production and metabolism (mitochondriogenesis, lactic acid removal), blood and …

Cytochrome P450-derived epoxyeicosatrienoic acids are potent vasodilators in preclinical
models and are hydrolyzed by soluble epoxide hydrolase (EPHX2). Associations between …