The instructive role of innate immunity in the acquired immune response

DT Fearon, RM Locksley - Science, 1996 - science.org
Innate immunity has been considered only to provide rapid, incomplete antimicrobial host
defense until the slower, more definitive acquired immune response develops. However …

γδ cells: a right time and a right place for a conserved third way of protection

AC Hayday - Annual review of immunology, 2000 - annualreviews.org
The tripartite subdivision of lymphocytes into B cells, αβ T cells, and γδ cells has been
conserved seemingly since the emergence of jawed vertebrates, more than 450 million …

Lysis of a Broad Range of Epithelial Tumour Cells by Human γδ T Cells: Involvement of NKG2D ligands and T‐cell Receptor‐ versus NKG2D‐dependent …

P Wrobel, H Shojaei, B Schittek… - Scandinavian …, 2007 - Wiley Online Library
Human γδ T cells expressing a Vγ9Vδ2 T‐cell receptor (TCR) kill various tumour cells
including autologous tumours. In addition to TCR‐dependent recognition, activation of …

TLR signalling and the function of dendritic cells

H Hemmi, S Akira - Mechanisms of epithelial defense, 2005 - karger.com
The recognition of microbes by innate immune cells initiates activation of the whole immune
system. Toll-like receptors (TLRs) are known to recognize various components of invading …

Interleukin 7 receptor-deficient mice lack gammadelta T cells.

K Maki, S Sunaga, Y Komagata… - Proceedings of the …, 1996 - National Acad Sciences
The interleukin 7 receptor (IL-7R) plays a crucial role in early B-and T-cell development. It
consists of a unique a chain and a common gamma chain [IL-2 receptor gamma chain (IL …

Recognition by γ/δ T cells

Y Chien, R Jores, MP Crowley - Annual review of immunology, 1996 - annualreviews.org
▪ Abstract In contrast with the study of αβ T cells, that of γδ T cells is relatively recent and
stems from the discovery of their rearranged genes, rather than from any knowledge of their …

gamma/delta and other unconventional T lymphocytes: what do they see and what do they do?

SH Kaufmann - Proceedings of the National Academy of …, 1996 - National Acad Sciences
T lymphocytes recognize specific ligands by clonally distributed T-cell receptors (TCR). In
humans and most animals, the vast majority of T cells express a TCR composed of an alpha …

[图书][B] Fundamentals of Oncology, revised and expanded

HC Pitot - 2002 - taylorfrancis.com
Compiling significant advances from more than a decade of research, this text presents
breakthroughs in the prevention, treatment, and control of cancer-exploring the origin …

Tumor immunology: the glass is half full

JA Sogn - Immunity, 1998 - cell.com
The goal of this review is to summarize where the field ultraviolet light (UV)-induced tumors
has been shown to of tumor immunology is today and to emphasize the require granulocytes …

An innate view of γδ T cells

R Boismenu, WL Havran - Current opinion in immunology, 1997 - Elsevier
Findings made during the past few years demonstrate that γδ T cells apparently share with
macrophages a propensity to recognize nonpeptidic molecules of the kind most commonly …