Recent major advances in understanding the molecular basis of acute myeloid leukemia
(AML) provide a double-edged sword. Although defining the topology and key features of …

This manuscript represents a review of lymphoblastic leukemia/lymphoma (acute
lymphoblastic leukemia/lymphoblastic lymphoma), acute leukemias of ambiguous lineage …

Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …

The introduction of all-trans retinoic acid (ATRA) and, more recently, arsenic trioxide (ATO)
into the therapy of acute promyelocytic leukemia (APL) has revolutionized the management …

This review highlights new findings that have deepened our understanding of the
mechanisms of leukemogenesis, therapy and resistance in acute promyelocytic leukemia …

Acute promyelocytic leukemia is the first malignant disease highly curable with targeted
therapy directed at a unique molecular abnormality. The characteristic bleeding diathesis is …

The prognostic impact of tyrosine kinase domain (TKD) mutations of the fms-like tyrosine
kinase-3 (FLT3) gene in acute myeloid leukemia (AML) is currently uncertain. To resolve this …

Acute myeloid leukemia (AML) is a heterogeneous group of leukemias that result from clonal
transformation of hematopoietic precursors through the acquisition of chromosomal …

We analyzed 2502 patients with acute myeloid leukemia at diagnosis for NRAS mutations
around the hot spots at codons 12, 13, and 61 and correlated the results to cytomorphology …

Coagulopathy occurs in most patients with (APML) and is life‐threatening; therefore prompt
diagnosis and recognition of any coagulation defect is imperative. Unfortunately …