Neurodevelopmental disorders (NDDs) impact multiple aspects of an individual's
functioning, including social interactions, communication, and behaviors. The underlying …

Thousand and one amino acid kinases (TAOKs) are relatively understudied and functionally
pleiotropic protein kinases that have emerged as important regulators of neurodevelopment …

Emotional stress is a leading risk factor in the development of neuropsychiatric disorders
possibly via immune activation. P2X7 receptors promote neuroinflammation, and research …

Context Extensive studies have provided considerable evidence suggesting the role of
inflammation in the development of female reproductive diseases. However, causality has …

Abstract N6-methyladenosine (m6A) methylation regulates gene expression/protein by
influencing numerous aspects of mRNA metabolism and contributes to neuropsychiatric …

Prescription of PCSK9-inhibitors has increased in recent years but not much is known about
its off-target effects. PCSK9-expression is evident in non-hepatic tissues, notably the brain …

Introduction: Comorbidities, such as gastroesophageal reflux disease (GERD), are common
in patients with rhinosinusitis (RS). However, the link between RS and GERD has not been …

Deciphering the genetic architecture of depression is pivotal for characterizing the
associated pathophysiological processes and development of new therapeutics. Here we …

The process of drug development is expensive and time-consuming. In contrast, drug
repurposing can be introduced to clinical practice more quickly and at a reduced cost. Over …

Abstract Opioid Use Disorder (OUD) is a chronic and relapsing condition characterized by
the misuse of opioid drugs, causing significant morbidity and mortality in the United States …