Thrombosis is a leading cause of death in cardiovascular diseases such as myocardial
infarction (MI), unstable angina and acute coronary syndrome (ACS) in the industrialized …

Norcoclaurine synthase (NCS) catalyzes a stereoselective Pictet–Spengler reaction to give
the key intermediate,(S)-norcoclaurine in benzylisoquinoline alkaloid biosynthesis. This …

The coagulation cascade is the process of the conversion of soluble fibrinogen to insoluble
fibrin that terminates in production of a clot. Factor Xa (FXa) is a serine protease involved in …

Human neutrophil elastase (HNE) is a serine protease that plays vital roles in inflammation,
innate immune response, and tissue remodeling processes. HNE has been actively pursued …

Venous thromboembolism including deep vein thrombosis and pulmonary embolism is an
abundant and dangerous disease with significant relapse probability and mortality. In pursuit …

The anticoagulant activity of lignosulfonic acid sodium (LSAS), a non-saccharide heparin
mimetic, was investigated in this study. LSAS is a relatively safe industrial byproduct with …

Coagulation factor Xa (fXa) is a particularly attractive target for the development of effective
and safe anticoagulants. In this study, novel 2, 3-dihydroquinazolin-4 (1 H)-one derivatives …

Abstract Introduction Factor Xa (FXa) plays an important role in blood coagulation. This
study investigated glycyrrhetinic acid, a small molecule derived from Chinese herbs, and …

Plasmin, a key serine protease, plays a major role in clot lysis and extracellular matrix
remodeling. Heparin, a natural polydisperse sulfated glycosaminoglycan, is known to …

Thrombin is the most potent platelet aggregator. To discover the selective inhibitor of
thrombin that is important to curing platelet aggregation-related diseases, docking …