The discovery in 2006 that loss-of-function mutations in the filaggrin gene (FLG) cause
ichthyosis vulgaris and can predispose to atopic dermatitis (AD) galvanized the dermatology …

Filaggrin Mutations Associated with Skin and Allergic Diseases | New England Journal of
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …

Atopic dermatitis often precedes the development of other atopic diseases. The atopic march
describes this temporal relationship in the natural history of atopic diseases. Although the …

The skin is the largest organ of the mammalian body. The outermost layer of mammalian
skin, the stratum corneum (SC) of the epidermis, consists of piles of dead corneocytes that …

The skin forms an effective barrier between the organism and the environment preventing
invasion of pathogens and fending off chemical and physical assaults, as well as the …

Over the past 150 years the skin's structure and function has been the subject of much
investigation by scientists. The stratum corneum (SC), the skin's outermost layer and …

BACKGROUND: Inherited ichthyoses belong to a large, clinically and etiologically
heterogeneous group of mendelian disorders of cornification, typically involving the entire …

Recently, loss-of-function mutations in FLG, the human gene encoding profilaggrin and
filaggrin, have been identified as the cause of the common skin condition ichthyosis vulgaris …

To provide a stable environmental barrier, the epidermis requires an integrated network of
cytoskeletal elements and cellular junctions. Nevertheless, the epidermis ranks among the …

Classic atopic dermatitis is complicated by asthma, allergic rhinitis, and food allergies,
cumulatively referred to as atopic diseases. Recent discoveries of mutations in the filaggrin …