The delivery of drugs to a target site frequently involves crossing biological barriers. The
degree and nature of the impediment to flux, as well as the potential approaches to …

Microporation involves the creation of micron-sized micropores or microchannels in the skin
which can then allow the transport of water soluble molecules and macromolecules …

Drug delivery technologies represent a vast and vital area of Research and Development.
The demand for innovative drug delivery systems continues to grow, and this growth …

Introduction: Using lasers can be an effective drug permeation-enhancement approach for
facilitating drug delivery into or across the skin. The controlled disruption and ablation of the …

Thermal ablation is a promising mechanism to increase permeability of the skin's outer
barrier layer of stratum corneum while sparing deeper living tissues. In this study, finite …

The objectives of this study were to investigate a novel laser microporation technology
(PLEASE Painless Laser Epidermal System) and to determine the effect of pore number and …

The objective of the study was to investigate the effect of laser microporation, using
PLEASE® technology, on diclofenac delivery kinetics. Skin transport of diclofenac was …

Driven by constantly increasing knowledge about skin immunology, vaccine delivery via the
cutaneous route has recently gained renewed interest. Considering its richness in …

The aim of the study was (i) to investigate the feasibility of using fractional laser ablation to
create micropore arrays in order to deliver proteins into and across the skin and (ii) to …

Since the approval of first transdermal patch (Transderm Scop®) containing scopolamine in
1979, the improvement in systemic drug delivery through skin remains incremental. The …