Selection of mouse models of cancer is often based simply on availability of a mouse strain
and a known compatible tumor. Frequently this results in use of tumor models long on …

Disseminated tumors are poorly accessible to nanoscale drug delivery systems because of
the vascular barrier, which attenuates extravasation at the tumor site. We investigated P …

Cancer stem cells (CSCs) have been positively identified and successfully isolated from
some but not all cancers. The studies on CSCs to date suggest that these cells are rare …

PD-L1 is expressed by a subset of patients with metastatic melanoma (MM) with an
unfavorable outcome. Its expression is increased in cells resistant to BRAF or MEK inhibitors …

Platelet endothelial cell adhesion molecule-1 (PECAM-1 or CD31) is a well-known marker of
endothelial cells and a key factor for adhesion and accumulation of platelets. CD31 plays …

The advancement of nanotechnology has led to the experimental development of cancer
therapeutics, which may overcome the shortcomings of commercially available drugs and …

Non-physiological mechanobiological stimuli typically occur in tumors and are considered to
promote cancer spreading. Non-fluid related pressure (solid stress), which arises as tumors …

Titanium dioxide (TiO 2) nanoparticles are widely used in cosmetics, sunscreen, electronics,
drug delivery systems, and diverse bio-application fields. In the workplace, the primary …

A fully automatic segmentation and morphological analysis algorithm for the analysis of
microvessels from CD31 immunostained histological tumour sections is presented …

Background Apoptosis caused by inadequate or inappropriate cell-matrix interactions is
defined as anoikis. Although transformed cells are known to be anoikis-resistant, the …