The fission yeast cell integrity pathway: a functional hub for cell survival upon stress and beyond
The survival of eukaryotic organisms during environmental changes is largely dependent on
the adaptive responses elicited by signal transduction cascades, including those regulated …
the adaptive responses elicited by signal transduction cascades, including those regulated …
Escaping nuclear decay: the significance of mRNA export for gene expression
A Tudek, M Schmid, TH Jensen - Current Genetics, 2019 - Springer
In this perspective, we discuss the regulatory impact of nuclear RNA export and decay on
messenger RNA (mRNA) functionality. It is well established that control of protein-coding …
messenger RNA (mRNA) functionality. It is well established that control of protein-coding …
Identification of ACA‐28, a 1′‐acetoxychavicol acetate analogue compound, as a novel modulator of ERK MAPK signaling, which preferentially kills human …
R Satoh, K Hagihara, K Matsuura, Y Manse… - Genes to …, 2017 - Wiley Online Library
The extracellular signal‐regulated kinase (ERK) signaling pathway is essential for cell
proliferation and is frequently deregulated in human tumors such as melanoma. Melanoma …
proliferation and is frequently deregulated in human tumors such as melanoma. Melanoma …
Long noncoding RNA LBX2‐AS1 promotes colorectal cancer progression via binding with PTBP1 and stabilizing KAT2A expression
A Zhao, Y Wang, F Lin, K Bai… - Journal of Biochemical and …, 2022 - Wiley Online Library
The long noncoding RNAs (lncRNAs) have been investigated in colorectal cancer (CRC).
The aim of this study is to identify the biological functions of LBX2‐AS1 in CRC. Quantitative …
The aim of this study is to identify the biological functions of LBX2‐AS1 in CRC. Quantitative …
RNA-Binding protein Rnc1 regulates cell length at division and acute stress response in fission yeast through negative feedback modulation of the Stress-Activated …
F Prieto-Ruiz, J Vicente-Soler, A Franco, E Gómez-Gil… - MBio, 2020 - Am Soc Microbiol
ABSTRACT RNA-binding proteins (RBPs) play a major role during control of mRNA
localization, stability, and translation and are central to most cellular processes. In the fission …
localization, stability, and translation and are central to most cellular processes. In the fission …
Rcn1, the fission yeast homolog of human DSCR1, regulates arsenite tolerance independently from calcineurin
T Takasaki, A Bamba, Y Kukita, A Nishida… - Genes to …, 2024 - Wiley Online Library
Calcineurin (CN) is a conserved Ca2+/calmodulin‐dependent phosphoprotein phosphatase
that plays a key role in Ca2+ signaling. Regulator of calcineurin 1 (RCAN1), also known as …
that plays a key role in Ca2+ signaling. Regulator of calcineurin 1 (RCAN1), also known as …
Discovery of new benzhydrol biscarbonate esters as potent and selective apoptosis inducers of human melanomas bearing the activated ERK pathway: SAR studies …
R Satoh, N Hamada, A Yamada, Y Kanda… - Bioorganic …, 2020 - Elsevier
The recent discovery that an ERK signaling modulator [ACA-28 (2a)] preferentially kills
human melanoma cell lines by inducing ERK-dependent apoptosis has generated …
human melanoma cell lines by inducing ERK-dependent apoptosis has generated …
The putative RNA-Binding protein Dri1 promotes the loading of kinesin-14/Klp2 to the mitotic spindle and is sequestered into heat-induced protein aggregates in …
M Yukawa, M Ohishi, Y Yamada, T Toda - International journal of …, 2021 - mdpi.com
Cells form a bipolar spindle during mitosis to ensure accurate chromosome segregation.
Proper spindle architecture is established by a set of kinesin motors and microtubule …
Proper spindle architecture is established by a set of kinesin motors and microtubule …
Rae1-mediated nuclear export of Rnc1 is an important determinant in controlling MAPK signaling
R Satoh, K Hagihara, R Sugiura - Current genetics, 2018 - Springer
In eukaryotic cells, RNA binding proteins (RBPs) play critical roles in regulating almost every
aspect of gene expression, often shuttling between the nucleus and the cytoplasm. They are …
aspect of gene expression, often shuttling between the nucleus and the cytoplasm. They are …
Distinct modes of stress granule assembly mediated by the KH‐type RNA‐binding protein Rnc1
R Satoh, N Hara, A Kawasaki, T Takasaki… - Genes to …, 2018 - Wiley Online Library
We have previously identified the KH‐type RNA‐binding protein Rnc1 as an important
regulator of the posttranscriptional expression of the MAPK phosphatase Pmp1 in fission …
regulator of the posttranscriptional expression of the MAPK phosphatase Pmp1 in fission …