Stable gastric pentadecapeptide BPC 157 may recover brain–gut axis and gut–brain axis function

P Sikiric, S Gojkovic, I Krezic, IM Smoday, L Kalogjera… - Pharmaceuticals, 2023 - mdpi.com
Conceptually, a wide beneficial effect, both peripherally and centrally, might have been
essential for the harmony of brain–gut and gut–brain axes' function. Seen from the original …

The therapeutic effects of low-intensity pulsed ultrasound in musculoskeletal soft tissue injuries: Focusing on the molecular mechanism

H Qin, L Du, Z Luo, Z He, Q Wang, S Chen… - … in Bioengineering and …, 2022 - frontiersin.org
Musculoskeletal soft tissue injuries are very common and usually occur during both sporting
and everyday activities. The intervention of adjuvant therapies to promote tissue …

Pentadecapeptide BPC 157 efficiently reduces radiation-induced liver injury and lipid accumulation through Kruppel-like factor 4 upregulation both in vivo and in vitro

BS Huang, SC Huang, FH Chen, Y Chang, HF Mei… - Life Sciences, 2022 - Elsevier
Aims Radiation-induced liver disease (RILD) is the major complication for cancer patients
after radiation therapy. We investigated the protective effects of BPC 157 peptide in reducing …

[HTML][HTML] Pentadecapeptide BPC 157 resolves suprahepatic occlusion of the inferior caval vein, Budd-Chiari syndrome model in rats

S Gojkovic, I Krezic, B Vrdoljak… - World journal of …, 2020 - ncbi.nlm.nih.gov
BACKGROUND Recently, as a possible therapy resolving solution, pentadecapeptide BPC
157 therapy, has been used in alleviating various vascular occlusion disturbances. BPC 157 …

BPC 157 therapy and the permanent occlusion of the superior sagittal sinus in rat: Vascular recruitment

S Gojkovic, I Krezic, H Vranes, H Zizek, D Drmic… - Biomedicines, 2021 - mdpi.com
We show the complex syndrome of the occluded superior sagittal sinus, brain swelling and
lesions and multiple peripheral organs lesions in rat. Recovery goes centrally and …

Occlusion of the superior mesenteric artery in rats reversed by collateral pathways activation: Gastric pentadecapeptide BPC 157 therapy counteracts multiple organ …

M Knezevic, S Gojkovic, I Krezic, H Zizek… - Biomedicines, 2021 - mdpi.com
Gastric pentadecapeptide BPC 157 therapy counteracts multiple organ dysfunction
syndrome in rats, which have permanent occlusion of the superior mesenteric artery close to …

Therapy of the rat hemorrhagic cystitis induced by cyclophosphamide. Stable gastric pentadecapeptide BPC 157, L-arginine, L-NAME

M Sucic, K Luetic, I Jandric, D Drmic, AZ Sever… - European journal of …, 2019 - Elsevier
We focused on the cyclophosphamide-induced hemorrhagic cystitis (100 mg/kg/day
intraperitoneally throughout three days) as a particular NO-system disturbance, and therapy …

Pentadecapeptide BPC 157 and the central nervous system

J Vukojević, M Milavić, D Perović, S Ilić… - Neural Regeneration …, 2022 - journals.lww.com
We reviewed the pleiotropic beneficial effects of the stable gastric pentadecapeptide BPC
157, three very recent demonstrations that may be essential in the gut-brain and brain-gut …

Intragastric application of aspirin, clopidogrel, cilostazol, and BPC 157 in rats: Platelet aggregation and blood clot

S Konosic, M Petricevic, V Ivancan… - Oxidative medicine …, 2019 - Wiley Online Library
We suggest that the stable gastric pentadecapeptide BPC 157 may rescue thrombocyte
function. We focused on the antithrombotic agent aspirin, clopidogrel, and cilostazol …

Stable gastric pentadecapeptide BPC 157 and wound healing

S Seiwerth, M Milavic, J Vukojevic, S Gojkovic… - Frontiers in …, 2021 - frontiersin.org
Significance: The antiulcer peptide, stable gastric pentadecapeptide BPC 157 (previously
employed in ulcerative colitis and multiple sclerosis trials, no reported toxicity (LD1 not …