Alcohol use disorder (AUD) is a highly prevalent but severely under-treated disorder, with
only three widely-approved pharmacotherapies. Given that AUD is a very heterogeneous …

Patients who suffer from alcohol use disorders (AUDs) usually go through various socio-
behavioral and pathophysiological changes that take place in the brain and other organs …

Repeated episodes of binge-like alcohol consumption produce anxiety, depression and
various deleterious effects including alterations in neurogenesis. While the involvement of …

Binge alcohol (ethanol) drinking is associated with profound adverse effects on our health
and society. Rimonabant (SR141716A), a CB1 receptor inverse agonist, was previously …

In the past century there have been incredible advances in the field of medical research, but
what hinders translation of this knowledge into effective treatment for human disease? There …

Alcohol use disorder (AUD) causes an alarming economic and health burden in the United
States. Unfortunately, this disease does not exist in isolation; AUD is highly comorbid with …

The use of alcohol causes significant morbidity and mortality across the globe. Alcohol use
disorder (AUD) is defined by the excessive use of this drug despite a negative impact on the …

Alcohol and nicotine are the most widely co-abused drugs. Both modify the activity of
dopaminergic (DA) neurons of the Ventral Tegmental Area (VTA) and lead to an increase in …

Adolescence is a critical period in brain development that coincides with the initiation of
alcohol use. Nicotinic acetylcholine receptors (nAChR) have been shown to modulate …

The high‐drinking‐in‐the‐dark (HDID) lines of mice were selectively bred for achieving high
blood alcohol levels in the drinking‐in‐the‐dark (DID) task and have served as a unique …