Tumour progression is modulated by the local microenvironment. This environment is
populated by many immune cells, of which macrophages are among the most abundant …

Immunotherapy is regarded as the most promising treatment for cancers. Various cancer
immunotherapies, including adoptive cellular immunotherapy, tumor vaccines, antibodies …

Infiltration of macrophages in and around tumor nest represents one of the most crucial
hallmarks during tumor progression. The mutual interactions with tumor cells and stromal …

Macrophages are a highly heterogeneous and plastic population of cells that are crucial for
tissue repair and regeneration. This has made macrophages a particularly attractive target …

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic interstitial pneumonia
with unknown causes. The incidence rate increases year by year and the prognosis is poor …

The responses of patients to tumor therapies vary due to tumor heterogeneity. Tumor
stratification has been attracting increasing attention for accurately distinguishing between …

Periodontitis (PD) is a common chronic infectious disease. The local inflammatory response
in the host may cause the destruction of supporting periodontal tissue. Macrophages play a …

The skin is a complex organ that has devised numerous strategies, such as physical,
chemical, and microbiological barriers, to protect the host from external insults. In addition …

Macrophage activation is intimately linked to metabolic reprogramming. Inflammatory (M1)
macrophages are able to sustain inflammatory responses and to kill pathogens, mostly by …

Rationale: Atherosclerosis is a chronic inflammatory disease that is driven by the interplay of
pro-and anti-inflammatory leukocytes in the aorta. Yet, the phenotypic and transcriptional …