Cervical cancer immunotherapy: facts and hopes

L Ferrall, KY Lin, RBS Roden, CF Hung, TC Wu - Clinical Cancer Research, 2021 - AACR
It is a sad fact that despite being almost completely preventable through human
papillomavirus (HPV) vaccination and screening, cervical cancer remains the fourth most …

Current status and future directions for the development of human papillomavirus vaccines

R Wang, H Huang, C Yu, X Li, Y Wang… - Frontiers in …, 2024 - frontiersin.org
The development of human papillomavirus (HPV) vaccines has made substantive progress,
as represented by the approval of five prophylactic vaccines since 2006. Generally, the …

Immunotherapy Against HPV16/18 Generates Potent TH1 and Cytotoxic Cellular Immune Responses

ML Bagarazzi, J Yan, MP Morrow, X Shen… - Science translational …, 2012 - science.org
Despite the development of highly effective prophylactic vaccines against human
papillomavirus (HPV) serotypes 16 and 18, prevention of cervical dysplasia and cancer in …

Phase II trial of imiquimod and HPV therapeutic vaccination in patients with vulval intraepithelial neoplasia

S Daayana, E Elkord, U Winters, M Pawlita… - British journal of …, 2010 - nature.com
Background: Vulval intraepithelial neoplasia (VIN) is a premalignant condition, which is
frequently associated with type HPV16 infection, and multifocal disease has high rates of …

DNA vaccines: developing new strategies against cancer

D Fioretti, S Iurescia, VM Fazio… - BioMed Research …, 2010 - Wiley Online Library
Due to their rapid and widespread development, DNA vaccines have entered into a variety
of human clinical trials for vaccines against various diseases including cancer. Evidence that …

RG1-VLP and other L2-based, broad-spectrum HPV vaccine candidates

B Huber, JW Wang, RBS Roden… - Journal of Clinical …, 2021 - mdpi.com
Licensed human papillomavirus (HPV) vaccines contain virus-like particles (VLPs) self-
assembled from L1 major-capsid proteins that are remarkably effective prophylactic …

Heat-shock proteins as powerful weapons in vaccine development

A Bolhassani, S Rafati - Expert review of vaccines, 2008 - Taylor & Francis
Heat-shock proteins (HSPs) have been known as multifunctional proteins. They facilitate the
folding and unfolding of proteins, participate in vesicular transport processes, prevent …

Growth factor receptor expression in anal squamous lesions: modifications associated with oncogenic human papillomavirus and human immunodeficiency virus

F Walker, L Abramowitz, D Benabderrahmane, X Duval… - Human pathology, 2009 - Elsevier
High prevalence of squamous anal lesions is linked to oncogenic human papillomavirus
(HPV). Human immunodeficiency virus (HIV) promotes anal carcinogenesis. Epidermal …

Therapeutic hpv DNA vaccines

K Lin, E Roosinovich, B Ma, CF Hung, TC Wu - Immunologic research, 2010 - Springer
It is now well established that most cervical cancers are causally associated with HPV
infection. This realization has led to efforts to control HPV-associated malignancy through …

Developments in L2-based human papillomavirus (HPV) vaccines

C Schellenbacher, RBS Roden, R Kirnbauer - Virus research, 2017 - Elsevier
Infections with sexually transmitted high-risk Human Papillomavirus (hrHPV), of which there
are at least 15 genotypes, are responsible for a tremendous disease burden by causing …