Forebrain development in vertebrates is regulated by transcription factors encoded by
homeobox, bHLH and forkhead gene families throughout the progressive and overlapping …

Higher cognition in humans, compared to other primates, is often attributed to an increased
brain size, especially forebrain cortical surface area. Brain size is determined through highly …

Layer 5 extratelencephalic (ET) neurons are present across neocortical areas and send
axons to multiple subcortical targets,,,,–. Two cardinal subtypes exist,:(1) Slco2a1 …

The commonalities and differences in cell-type-specific pathways that lead to Alzheimer
disease (AD) and Parkinson disease (PD) remain unknown. Here, we performed a single …

Cortical function critically depends on inhibitory/excitatory balance. Cortical inhibitory
interneurons (cINs) are born in the ventral forebrain and migrate into cortex, where their …

Cross-species comparative analyses of single-cell RNA sequencing (scRNA-seq) data allow
us to explore, at single-cell resolution, the origins of the cellular diversity and evolutionary …

Exercise has been recognized as a beneficial factor for cognitive health, particularly in
relation to the hippocampus, a vital brain region responsible for learning and memory …

The mammalian telencephalon contains distinct GABAergic projection neuron and
interneuron types, originating in the germinal zone of the embryonic basal ganglia. How …

The nucleus accumbens (NAc) is a key brain region involved in reward processing and is
linked to multiple neuropsychiatric conditions such as substance use disorder, depression …

MEIS1 and MEIS2 encode highly conserved homeodomain transcription factors crucial for
developmental processes in a wide range of tissues, including the brain. They can execute …