During foetal development, neonatal period and childhood, the immune system is constantly
maturing. In the foetus, infection responsiveness is low and associates with spontaneous …

Nearly all human beings, by the time they reach adolescence, are infected with multiple
herpesviruses. At any given time, this family of viruses accounts for 35–40 billion human …

Chronic Fatigue Syndrome (CFS) is a complex illness affecting 4 million Americans for
which no characteristic lesion has been identified. Instead of searching for a deficiency in …

Natural killer (NK) cells differentiate and mature during the human life course; human
cytomegalovirus (HCMV) infection is a known driver of this process. We have explored …

Objectives To investigate the associations of environmental MS risk factors with clinical and
MRI measures of progression in high-risk clinically isolated syndromes (CIS) after the first …

Background Epstein-Barr virus (EBV) is an important human pathogen; it infects> 90%
people globally and is linked to infectious mononucleosis and several types of cancer …

Epstein-Barr virus (EBV) is typically acquired asymptomatically in childhood. In contrast,
infection later in life often leads to infectious mononucleosis (IM), a febrile illness …

During childhood, infections with cytomegalovirus (CMV) and Epstein-Barr virus (EBV) can
occur in close temporal proximity. Active, as well as latent, CMV infection is associated with …

Natural killer (NK) cells are an important component of innate immune responses to
infectious diseases. They mediate protection by being able to rapidly lyse infected cells and …

Background HIV-infected infants in sub-Saharan Africa have rapid disease progression. We
hypothesized that co-infection with cytomegalovirus (CMV) or Epstein Barr virus (EBV) …